Peter Smibert
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Explore the profile of Peter Smibert including associated specialties, affiliations and a list of published articles.
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Citations
21864
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Recent Articles
1.
Izzo F, Myers R, Ganesan S, Mekerishvili L, Kottapalli S, Prieto T, et al.
Nature
. 2024 May;
629(8014):1149-1157.
PMID: 38720070
In somatic tissue differentiation, chromatin accessibility changes govern priming and precursor commitment towards cellular fates. Therefore, somatic mutations are likely to alter chromatin accessibility patterns, as they disrupt differentiation topologies...
2.
Ivanova E, Shwetar J, Devlin J, Buus T, Gray-Gaillard S, Koide A, et al.
iScience
. 2024 Jan;
26(12):108572.
PMID: 38213787
SARS-CoV-2 infection and vaccination elicit potent immune responses. Our study presents a comprehensive multimodal single-cell analysis of blood from COVID-19 patients and healthy volunteers receiving the SARS-CoV-2 vaccine and booster....
3.
Lareau C, Dubois S, Buquicchio F, Hsieh Y, Garg K, Kautz P, et al.
Nat Genet
. 2023 Jun;
55(7):1198-1209.
PMID: 37386249
Pathogenic mutations in mitochondrial DNA (mtDNA) compromise cellular metabolism, contributing to cellular heterogeneity and disease. Diverse mutations are associated with diverse clinical phenotypes, suggesting distinct organ- and cell-type-specific metabolic vulnerabilities....
4.
Morris J, Caragine C, Daniloski Z, Domingo J, Barry T, Lu L, et al.
Science
. 2023 May;
380(6646):eadh7699.
PMID: 37141313
Most variants associated with complex traits and diseases identified by genome-wide association studies (GWAS) map to noncoding regions of the genome with unknown effects. Using ancestrally diverse, biobank-scale GWAS data,...
5.
Mimitou E, Smibert P, Lareau C
Methods Mol Biol
. 2023 Feb;
2611:249-267.
PMID: 36807072
While methods such as the Assay for Transposase Accessible Chromatin by sequencing (ATAC-seq) enable a comprehensive characterization of regulatory DNA, additional measurements are required to characterize the multifaceted nature of...
6.
Wessels H, Mendez-Mancilla A, Hao Y, Papalexi E, Mauck 3rd W, Lu L, et al.
Nat Methods
. 2022 Dec;
20(1):86-94.
PMID: 36550277
Pooled CRISPR screens coupled with single-cell RNA-sequencing have enabled systematic interrogation of gene function and regulatory networks. Here, we introduce Cas13 RNA Perturb-seq (CaRPool-seq), which leverages the RNA-targeting CRISPR-Cas13d system...
7.
Zhang B, Srivastava A, Mimitou E, Stuart T, Raimondi I, Hao Y, et al.
Nat Biotechnol
. 2022 Mar;
40(8):1220-1230.
PMID: 35332340
Technologies that profile chromatin modifications at single-cell resolution offer enormous promise for functional genomic characterization, but the sparsity of the measurements and integrating multiple binding maps represent substantial challenges. Here...
8.
Pandit K, Petrescu J, Cuevas M, Stephenson W, Smibert P, Phatnani H, et al.
Sci Rep
. 2022 Mar;
12(1):5081.
PMID: 35332182
Fluorescence microscopy is a key method in the life sciences. State of the art -omics methods combine fluorescence microscopy with complex protocols to visualize tens to thousands of features in...
9.
Legut M, Gajic Z, Guarino M, Daniloski Z, Rahman J, Xue X, et al.
Nature
. 2022 Mar;
603(7902):728-735.
PMID: 35296855
The engineering of autologous patient T cells for adoptive cell therapies has revolutionized the treatment of several types of cancer. However, further improvements are needed to increase response and cure...
10.
Stephenson W, Razaghi R, Busan S, Weeks K, Timp W, Smibert P
Cell Genom
. 2022 Mar;
2(2).
PMID: 35252946
Modifications are present on many classes of RNA, including tRNA, rRNA, and mRNA. These modifications modulate diverse biological processes such as genetic recoding and mRNA export and folding. In addition,...