Rahul Satija
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Explore the profile of Rahul Satija including associated specialties, affiliations and a list of published articles.
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91
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42093
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Recent Articles
1.
Borner K, Blood P, Silverstein J, Ruffalo M, Satija R, Teichmann S, et al.
Nat Methods
. 2025 Mar;
PMID: 40082611
The Human BioMolecular Atlas Program (HuBMAP) aims to construct a 3D Human Reference Atlas (HRA) of the healthy adult body. Experts from 20+ consortia collaborate to develop a Common Coordinate...
2.
Jiang L, Dalgarno C, Papalexi E, Mascio I, Wessels H, Yun H, et al.
Nat Cell Biol
. 2025 Feb;
27(3):505-517.
PMID: 40011560
Recent advancements in functional genomics have provided an unprecedented ability to measure diverse molecular modalities, but predicting causal regulatory relationships from observational data remains challenging. Here, we leverage pooled genetic...
3.
Gupta S, Niels Groen S, Zaidem M, Sajise A, Calic I, Natividad M, et al.
Elife
. 2025 Feb;
13.
PMID: 39976326
Populations can adapt to stressful environments through changes in gene expression. However, the fitness effect of gene expression in mediating stress response and adaptation remains largely unexplored. Here, we use...
4.
Blair J, Hartman A, Zenk F, Wahle P, Brancati G, Dalgarno C, et al.
Nat Commun
. 2025 Feb;
16(1):1346.
PMID: 39905064
Cell signaling plays a critical role in neurodevelopment, regulating cellular behavior and fate. While multimodal single-cell sequencing technologies are rapidly advancing, scalable and flexible profiling of cell signaling states alongside...
5.
Zhang Z, Schaefer C, Jiang W, Lu Z, Lee J, Sziraki A, et al.
Science
. 2024 Nov;
387(6731):eadn3949.
PMID: 39607904
To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling >20 million cells from 623 mouse tissues across different life stages, sexes, and genotypes. This comprehensive...
6.
Nakatsuka N, Adler D, Jiang L, Hartman A, Cheng E, Klann E, et al.
bioRxiv
. 2024 Oct;
PMID: 39463993
We assessed the reproducibility of differentially expressed genes (DEGs) in previously published Alzheimer's (AD), Parkinson's (PD), Schizophrenia (SCZ), and COVID-19 scRNA-seq studies. While transcriptional scores from DEGs of individual PD...
7.
Tiedje V, Vela P, Yang J, Untch B, Boucai L, Stonestrom A, et al.
bioRxiv
. 2024 Oct;
PMID: 39415999
Anaplastic thyroid cancer (ATC) is a clinically aggressive malignancy with a dismal prognosis. Combined BRAF/MEK inhibition offers significant therapeutic benefit in patients with -mutant ATCs. However, relapses are common and...
8.
Missarova A, Dann E, Rosen L, Satija R, Marioni J
Genome Biol
. 2024 Jul;
25(1):189.
PMID: 39026254
Single-cell RNA-sequencing enables testing for differential expression (DE) between conditions at a cell type level. While powerful, one of the limitations of such approaches is that the sensitivity of DE...
9.
Kowalski M, Wessels H, Linder J, Dalgarno C, Mascio I, Choudhary S, et al.
Cell
. 2024 Jun;
187(16):4408-4425.e23.
PMID: 38925112
Most mammalian genes have multiple polyA sites, representing a substantial source of transcript diversity regulated by the cleavage and polyadenylation (CPA) machinery. To better understand how these proteins govern polyA...
10.
Aihara G, Clifton K, Chen M, Li Z, Atta L, Miller B, et al.
Bioinformatics
. 2024 Jun;
40(7).
PMID: 38902953
Motivation: Spatial omics data demand computational analysis but many analysis tools have computational resource requirements that increase with the number of cells analyzed. This presents scalability challenges as researchers use...