Edward Scolnick
Overview
Explore the profile of Edward Scolnick including associated specialties, affiliations and a list of published articles.
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11
Citations
2588
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Recent Articles
1.
Singh T, Poterba T, Curtis D, Akil H, Eissa M, Barchas J, et al.
Nature
. 2022 Apr;
604(7906):509-516.
PMID: 35396579
Rare coding variation has historically provided the most direct connections between gene function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 schizophrenia cases and 97,322 controls, we implicate...
2.
Wagner F, Benajiba L, Campbell A, Weiwer M, Sacher J, Gale J, et al.
Sci Transl Med
. 2018 Mar;
10(431).
PMID: 29515000
Glycogen synthase kinase 3 (GSK3), a key regulatory kinase in the wingless-type MMTV integration site family (WNT) pathway, is a therapeutic target of interest in many diseases. Although dual GSK3α/β...
3.
Weiwer M, Xu Q, Gale J, Lewis M, Campbell A, Schroeder F, et al.
ACS Chem Biol
. 2018 Feb;
13(4):1038-1047.
PMID: 29485852
Schizophrenia is a severe neuropsychiatric disease that lacks completely effective and safe therapies. As a polygenic disorder, genetic studies have only started to shed light on its complex etiology. To...
4.
Wagner F, Bishop J, Gale J, Shi X, Walk M, Ketterman J, et al.
ACS Chem Biol
. 2016 Apr;
11(7):1952-63.
PMID: 27128528
The mood stabilizer lithium, the first-line treatment for bipolar disorder, is hypothesized to exert its effects through direct inhibition of glycogen synthase kinase 3 (GSK3) and indirectly by increasing GSK3's...
5.
Ripke S, ODushlaine C, Chambert K, Moran J, Kahler A, Akterin S, et al.
Nat Genet
. 2013 Aug;
45(10):1150-9.
PMID: 23974872
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish...
6.
Lee S, Ripke S, Neale B, Faraone S, Purcell S, Perlis R, et al.
Nat Genet
. 2013 Aug;
45(9):984-94.
PMID: 23933821
Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology,...
7.
Akil H, Brenner S, Kandel E, Kendler K, King M, Scolnick E, et al.
Science
. 2010 Mar;
327(5973):1580-1.
PMID: 20339051
No abstract available.
8.
Nyegaard M, Severinsen J, Als T, Hedemand A, Straarup S, Nordentoft M, et al.
Am J Med Genet B Neuropsychiatr Genet
. 2009 Aug;
153B(2):582-591.
PMID: 19693800
A recent study published by our group implicated the bromodomain containing protein 1 (BRD1) gene located at chromosome 22q13.33 with schizophrenia (SZ) and bipolar affective disorder (BPD) susceptibility and provided...
9.
Lichtenstein P, Bjork C, Hultman C, Scolnick E, Sklar P, Sullivan P
Psychol Med
. 2006 Jul;
36(10):1417-25.
PMID: 16863597
Objective: Recurrence risk estimates for schizophrenia are fundamental to our understanding of this complex disease. Widely cited estimates are from small/older samples. If these estimates are biased upwards, then the...
10.
Scolnick E
Schizophr Res
. 2004 Nov;
72(1):75-7.
PMID: 15531409
Cognitive dysfunction in patients who suffer from schizophrenia is a major clinical problem. For such patients, the neurobiological cause(s) for the cognition deficits are not clear. Treatments with high doses...