Edward Grimley
Overview
Explore the profile of Edward Grimley including associated specialties, affiliations and a list of published articles.
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11
Citations
237
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Recent Articles
1.
Bai S, Taylor S, Jamalruddin M, McGonigal S, Grimley E, Yang D, et al.
Mol Cancer Ther
. 2022 Jun;
21(9):1473-1484.
PMID: 35732503
Approximately 20% of high-grade serous ovarian cancers (HGSOC) have CCNE1 amplification. CCNE1-amplified tumors are homologous recombination (HR) proficient and resistant to standard therapies. Therapy resistance is associated with increased numbers...
2.
Bradford S, Grimley E, Laszczyk A, Lee P, Patel S, Dressler G
Cell Chem Biol
. 2021 Nov;
29(3):412-422.e4.
PMID: 34822752
The Pax family of developmental control genes are frequently deregulated in human disease. In the kidney, Pax2 is expressed in developing nephrons but not in adult proximal and distal tubules,...
3.
Grimley E, Cole A, Luong T, McGonigal S, Sinno S, Yang D, et al.
Theranostics
. 2021 Mar;
11(8):3540-3551.
PMID: 33664846
: Aldehyde dehydrogenase (ALDH) enzymes are often upregulated in cancer cells and associated with therapeutic resistance. ALDH enzymes protect cells by metabolizing toxic aldehydes which can induce DNA double stand...
4.
Huddle B, Grimley E, Chtcherbinine M, Buchman C, Takahashi C, Debnath B, et al.
Eur J Med Chem
. 2020 Dec;
211:113060.
PMID: 33341649
There is strong evidence that inhibition of one or more Aldehyde Dehydrogenase 1A (ALDH1A) isoforms may be beneficial in chemotherapy-resistant ovarian cancer and other tumor types. While many previous efforts...
5.
Chefetz I, Grimley E, Yang K, Hong L, Vinogradova E, Suciu R, et al.
Cell Rep
. 2019 Mar;
26(11):3061-3075.e6.
PMID: 30865894
Ovarian cancer is typified by the development of chemotherapy resistance. Chemotherapy resistance is associated with high aldehyde dehydrogenase (ALDH) enzymatic activity, increased cancer "stemness," and expression of the stem cell...
6.
Bradford S, Ranghini E, Grimley E, Lee P, Dressler G
J Biol Chem
. 2019 Jan;
294(9):3125-3136.
PMID: 30602563
Bone morphogenetic protein (BMP) signaling is critical in renal development and disease. In animal models of chronic kidney disease (CKD), re-activation of BMP signaling is reported to be protective by...
7.
Huddle B, Grimley E, Buchman C, Chtcherbinine M, Debnath B, Mehta P, et al.
J Med Chem
. 2018 Sep;
61(19):8754-8773.
PMID: 30221940
Aldehyde dehydrogenase (ALDH) activity is commonly used as a marker to identify cancer stem-like cells. The three ALDH1A isoforms have all been individually implicated in cancer stem-like cells and in...
8.
Grimley E, Dressler G
Kidney Int
. 2018 Apr;
94(2):259-267.
PMID: 29685496
Pax genes encode developmental regulators that are expressed in a variety of tissues and control critical events in morphogenesis. In the kidney, Pax2 and Pax8 are expressed in embryonic development...
9.
Soofi A, Wolf K, Emont M, Qi N, Martinez-Santibanez G, Grimley E, et al.
J Biol Chem
. 2017 Apr;
292(22):9051-9062.
PMID: 28424263
Obesity and its associated complications such as insulin resistance and non-alcoholic fatty liver disease are reaching epidemic proportions. In mice, the TGF-β superfamily is implicated in the regulation of white...
10.
Grimley E, Liao C, Ranghini E, Nikolovska-Coleska Z, Dressler G
ACS Chem Biol
. 2017 Jan;
12(3):724-734.
PMID: 28094913
The Pax gene family encodes DNA binding transcription factors that control critical steps in embryonic development and differentiation of specific cell lineages. Often, Pax proteins are re-expressed or ectopically expressed...