Ronald J Buckanovich
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Explore the profile of Ronald J Buckanovich including associated specialties, affiliations and a list of published articles.
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86
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3836
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Recent Articles
1.
Garcia G, Orellana T, Gorecki G, Frisbie L, Baruwal R, Suresh S, et al.
Cancer Discov
. 2025 Mar;
PMID: 40084985
The fundamental steps in high-grade serous ovarian cancer (HGSOC) initiation are unclear presenting critical barriers in prevention and early detection of this deadly disease. Current models propose that fallopian tube...
2.
Jiang Q, Jiang Q, Ertel M, Arrigo A, Sannino S, Goeckeler-Fried J, et al.
bioRxiv
. 2025 Feb;
PMID: 39990343
Cytotoxic chemotherapy remains the primary treatment for ovarian cancer (OvCa). Development of chemoresistance typically results in patient death within two years. As such, understanding chemoresistance is critical. One underexplored mechanism...
3.
Panesso-Gomez S, Cole A, Wield A, Anyaeche V, Shah J, Jiang Q, et al.
bioRxiv
. 2024 Nov;
PMID: 39605642
Chemoresistance is a major driver of cancer deaths. One understudied mechanism of chemoresistance is quiescence. We used single cell culture to identify, retrieve, and RNA-Seq profile primary quiescent ovarian cancer...
4.
Hamze Sinno S, Imperatore J, Bai S, Gomes-Jourdan N, Mafarachisi N, Coronnello C, et al.
J Clin Invest
. 2024 Sep;
134(21).
PMID: 39312740
Tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs) play a critical role in resistance to immunotherapy. In this study, we identified epidermal growth factor-like 6 (Egfl6) as a regulator of...
5.
Sharrow A, Megill E, Chen A, Farooqi A, Tangudu N, Uboveja A, et al.
Mol Metab
. 2024 Sep;
89:102031.
PMID: 39304063
Quiescence is a reversible cell cycle exit traditionally thought to be associated with a metabolically inactive state. Recent work in muscle cells indicates that metabolic reprogramming is associated with quiescence....
6.
Sharrow A, Megill E, Chen A, Farooqi A, McGonigal S, Hempel N, et al.
bioRxiv
. 2024 Jul;
PMID: 39026889
Quiescence is a reversible cell cycle exit traditionally thought to be associated with a metabolically inactive state. Recent work in muscle cells indicates that metabolic reprogramming is associated with quiescence....
7.
Landen C, Buckanovich R, Sill M, Mannel R, Walker J, DiSilvestro P, et al.
J Clin Oncol
. 2024 May;
42(21):2537-2545.
PMID: 38776484
Purpose: The interleukin-6/Janus kinase (JAK)/signal transducers and activators of transcription 3 axis is a reported driver of chemotherapy resistance. We hypothesized that adding the JAK1/2 inhibitor ruxolitinib to standard chemotherapy...
8.
Garrett A, Bai S, Cascio S, Gupta N, Yang D, Buckanovich R
Gynecol Oncol
. 2024 Feb;
185:75-82.
PMID: 38368816
Objective: EGFL6, a growth factor produced by adipocytes, is upregulated in and implicated in the tumorigenesis of multiple tumor types. Given the strong link between obesity and endometrial cancer, we...
9.
Takahashi C, Chtcherbinine M, Huddle B, Wilson M, Emmel T, Hohlman R, et al.
Chem Biol Interact
. 2024 Feb;
391:110910.
PMID: 38364885
Aldehyde dehydrogenase 1A (ALDH1A) isoforms may be a useful target for overcoming chemotherapy resistance in high-grade serous ovarian cancer (HGSOC) and other solid tumor cancers. However, as different cancers express...
10.
Zhang L, Cascio S, Mellors J, Buckanovich R, Osmanbeyoglu H
Commun Biol
. 2024 Jan;
7(1):20.
PMID: 38182756
High-grade serous ovarian carcinoma (HGSOC) is a heterogeneous disease, and a highstromal/desmoplastic tumor microenvironment (TME) is associated with a poor outcome. Stromal cell subtypes, including fibroblasts, myofibroblasts, and cancer-associated mesenchymal...