E Christopher Partridge
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Explore the profile of E Christopher Partridge including associated specialties, affiliations and a list of published articles.
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19
Citations
1707
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Recent Articles
1.
Roberts B, Anderson A, Partridge E, Cooper G, Myers R
Genome Res
. 2024 Apr;
34(4):620-632.
PMID: 38631728
Differential gene expression in response to perturbations is mediated at least in part by changes in binding of transcription factors (TFs) and other proteins at specific genomic regions. Association of...
2.
Moyers B, Partridge E, Mackiewicz M, Betti M, Darji R, Meadows S, et al.
Genome Res
. 2023 Oct;
33(11):1879-1892.
PMID: 37852782
Transcription factors (TFs) are -acting proteins that bind -regulatory elements (CREs) in DNA to control gene expression. Here, we analyzed the genomic localization profiles of 529 sequence-specific TFs and 151...
3.
Hiatt S, Trajkova S, Rossi Sebastiano M, Partridge E, Abidi F, Anderson A, et al.
Am J Hum Genet
. 2022 Dec;
110(2):215-227.
PMID: 36586412
Neurodevelopmental disorders (NDDs) result from highly penetrant variation in hundreds of different genes, some of which have not yet been identified. Using the MatchMaker Exchange, we assembled a cohort of...
4.
Hiatt S, Lawlor J, Handley L, Ramaker R, Rogers B, Partridge E, et al.
HGG Adv
. 2021 May;
2(2).
PMID: 33937879
Exome and genome sequencing have proven to be effective tools for the diagnosis of neurodevelopmental disorders (NDDs), but large fractions of NDDs cannot be attributed to currently detectable genetic variation....
5.
Roberts B, Partridge E, Moyers B, Agarwal V, Newberry K, Martin B, et al.
Genome Res
. 2021 Apr;
31(5):866-876.
PMID: 33879525
Massively parallel reporter assays (MPRAs) are useful tools to characterize regulatory elements in human genomes. An aspect of MPRAs that is not typically the focus of analysis is their intrinsic...
6.
Bowling K, Thompson M, Gray D, Lawlor J, Williams K, East K, et al.
Genet Med
. 2020 Sep;
23(2):280-288.
PMID: 32989269
Purpose: To evaluate the effectiveness and specificity of population-based genomic screening in Alabama. Methods: The Alabama Genomic Health Initiative (AGHI) has enrolled and evaluated 5369 participants for the presence of...
7.
Partridge E, Chhetri S, Prokop J, Ramaker R, Jansen C, Goh S, et al.
Nature
. 2020 Jul;
583(7818):720-728.
PMID: 32728244
Transcription factors are DNA-binding proteins that have key roles in gene regulation. Genome-wide occupancy maps of transcriptional regulators are important for understanding gene regulation and its effects on diverse biological...
8.
Ramaker R, Hardigan A, Goh S, Partridge E, Wold B, Cooper S, et al.
Genome Res
. 2020 Jul;
30(7):939-950.
PMID: 32616518
DNA-associated proteins (DAPs) classically regulate gene expression by binding to regulatory loci such as enhancers or promoters. As expanding catalogs of genome-wide DAP binding maps reveal thousands of loci that,...
9.
Meadows S, Brandsmeier L, Newberry K, Betti M, Nesmith A, Mackiewicz M, et al.
Methods Mol Biol
. 2020 Jan;
2117:3-34.
PMID: 31960370
Chromatin immunoprecipitation followed by next-generation DNA sequencing (ChIP-seq) has been used to identify transcription factor (TF) binding proteins throughout the genome. Unfortunately, this approach traditionally requires commercially available, ChIP-seq grade...
10.
McDaniel J, Varley K, Gertz J, Savic D, Roberts B, Bailey S, et al.
Oncotarget
. 2016 Dec;
8(5):8226-8238.
PMID: 28030809
Breast cancer is a heterogeneous disease comprised of four molecular subtypes defined by whether the tumor-originating cells are luminal or basal epithelial cells. Breast cancers arising from the luminal mammary...