Brian S Roberts
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Explore the profile of Brian S Roberts including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
1163
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0
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Recent Articles
1.
Roberts B, Anderson A, Partridge E, Cooper G, Myers R
Genome Res
. 2024 Apr;
34(4):620-632.
PMID: 38631728
Differential gene expression in response to perturbations is mediated at least in part by changes in binding of transcription factors (TFs) and other proteins at specific genomic regions. Association of...
2.
Rogers B, Anderson A, Lauzon S, Davis M, Hauser R, Roberts S, et al.
Am J Hum Genet
. 2024 Jan;
111(2):259-279.
PMID: 38232730
Tauopathies are a group of neurodegenerative diseases defined by abnormal aggregates of tau, a microtubule-associated protein encoded by MAPT. MAPT expression is near absent in neural progenitor cells (NPCs) and...
3.
Rogers B, Anderson A, Lauzon S, Davis M, Hauser R, Roberts S, et al.
bioRxiv
. 2023 Apr;
PMID: 37090552
Background: Tauopathies are a group of neurodegenerative diseases driven by abnormal aggregates of tau, a microtubule associated protein encoded by the gene. expression is absent in neural progenitor cells (NPCs)...
4.
Roberts B, Partridge E, Moyers B, Agarwal V, Newberry K, Martin B, et al.
Genome Res
. 2021 Apr;
31(5):866-876.
PMID: 33879525
Massively parallel reporter assays (MPRAs) are useful tools to characterize regulatory elements in human genomes. An aspect of MPRAs that is not typically the focus of analysis is their intrinsic...
5.
Vaklavas C, Roberts B, Varley K, Lin N, Liu M, Rugo H, et al.
Breast Cancer Res
. 2020 Feb;
22(1):22.
PMID: 32070401
Background: In preclinical studies, the expression of vascular endothelial growth factor (VEGF) in hormone receptor-positive breast cancer is associated with estrogen-independent tumor growth and resistance to endocrine therapies. This study...
6.
Hardigan A, Roberts B, Moore D, Ramaker R, Jones A, Myers R
Nucleic Acids Res
. 2019 Jun;
47(14):e84.
PMID: 31165880
In small RNA (smRNA) sequencing studies, highly abundant molecules such as adapter dimer products and tissue-specific microRNAs (miRNAs) inhibit accurate quantification of lowly expressed species. We previously developed a method...
7.
Roberts B, Hardigan A, Moore D, Ramaker R, Jones A, Fitz-Gerald M, et al.
Clin Cancer Res
. 2018 Mar;
24(9):2092-2099.
PMID: 29490987
Colorectal cancer is the third most common cancer worldwide, causing approximately 700,000 deaths each year. The majority of colorectal cancers begin as adenomas. Definitive screening for colorectal adenomas is currently...
8.
Kirby M, Ramaker R, Roberts B, Lasseigne B, Gunther D, Burwell T, et al.
BMC Cancer
. 2017 Apr;
17(1):273.
PMID: 28412973
Background: Current diagnostic tools for prostate cancer lack specificity and sensitivity for detecting very early lesions. DNA methylation is a stable genomic modification that is detectable in peripheral patient fluids...
9.
Alonso A, Lasseigne B, Williams K, Nielsen J, Ramaker R, Hardigan A, et al.
Bioinformatics
. 2017 Jan;
33(11):1727-1729.
PMID: 28108448
Summary: The wide range of RNA-seq applications and their high-computational needs require the development of pipelines orchestrating the entire workflow and optimizing usage of available computational resources. We present aRNApipe,...
10.
McDaniel J, Varley K, Gertz J, Savic D, Roberts B, Bailey S, et al.
Oncotarget
. 2016 Dec;
8(5):8226-8238.
PMID: 28030809
Breast cancer is a heterogeneous disease comprised of four molecular subtypes defined by whether the tumor-originating cells are luminal or basal epithelial cells. Breast cancers arising from the luminal mammary...