Mark Mackiewicz
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Explore the profile of Mark Mackiewicz including associated specialties, affiliations and a list of published articles.
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20
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1464
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Recent Articles
1.
Rogers B, Anderson A, Lauzon S, Davis M, Hauser R, Roberts S, et al.
Am J Hum Genet
. 2024 Jan;
111(2):259-279.
PMID: 38232730
Tauopathies are a group of neurodegenerative diseases defined by abnormal aggregates of tau, a microtubule-associated protein encoded by MAPT. MAPT expression is near absent in neural progenitor cells (NPCs) and...
2.
Moyers B, Partridge E, Mackiewicz M, Betti M, Darji R, Meadows S, et al.
Genome Res
. 2023 Oct;
33(11):1879-1892.
PMID: 37852782
Transcription factors (TFs) are -acting proteins that bind -regulatory elements (CREs) in DNA to control gene expression. Here, we analyzed the genomic localization profiles of 529 sequence-specific TFs and 151...
3.
Rogers B, Anderson A, Lauzon S, Davis M, Hauser R, Roberts S, et al.
bioRxiv
. 2023 Apr;
PMID: 37090552
Background: Tauopathies are a group of neurodegenerative diseases driven by abnormal aggregates of tau, a microtubule associated protein encoded by the gene. expression is absent in neural progenitor cells (NPCs)...
4.
Rozowsky J, Gao J, Borsari B, Yang Y, Galeev T, Gursoy G, et al.
Cell
. 2023 Mar;
186(7):1493-1511.e40.
PMID: 37001506
Understanding how genetic variants impact molecular phenotypes is a key goal of functional genomics, currently hindered by reliance on a single haploid reference genome. Here, we present the EN-TEx resource...
5.
Moore J, Purcaro M, Pratt H, Epstein C, Shoresh N, Adrian J, et al.
Nature
. 2022 Apr;
605(7909):E3.
PMID: 35474001
No abstract available.
6.
Moore J, Purcaro M, Pratt H, Epstein C, Shoresh N, Adrian J, et al.
Nature
. 2020 Jul;
583(7818):699-710.
PMID: 32728249
The human and mouse genomes contain instructions that specify RNAs and proteins and govern the timing, magnitude, and cellular context of their production. To better delineate these elements, phase III...
7.
Partridge E, Chhetri S, Prokop J, Ramaker R, Jansen C, Goh S, et al.
Nature
. 2020 Jul;
583(7818):720-728.
PMID: 32728244
Transcription factors are DNA-binding proteins that have key roles in gene regulation. Genome-wide occupancy maps of transcriptional regulators are important for understanding gene regulation and its effects on diverse biological...
8.
Meadows S, Brandsmeier L, Newberry K, Betti M, Nesmith A, Mackiewicz M, et al.
Methods Mol Biol
. 2020 Jan;
2117:3-34.
PMID: 31960370
Chromatin immunoprecipitation followed by next-generation DNA sequencing (ChIP-seq) has been used to identify transcription factor (TF) binding proteins throughout the genome. Unfortunately, this approach traditionally requires commercially available, ChIP-seq grade...
9.
Rahmanian S, Murad R, Breschi A, Zeng W, Mackiewicz M, Williams B, et al.
Genome Res
. 2019 Oct;
29(11):1900-1909.
PMID: 31645363
MicroRNAs (miRNAs) play a critical role as posttranscriptional regulators of gene expression. The ENCODE Project profiled the expression of miRNAs in an extensive set of organs during a time-course of...
10.
Venkataraman A, Yang K, Irizarry J, Mackiewicz M, Mita P, Kuang Z, et al.
Nat Methods
. 2018 Apr;
15(5):330-338.
PMID: 29638227
A key component of efforts to address the reproducibility crisis in biomedical research is the development of rigorously validated and renewable protein-affinity reagents. As part of the US National Institutes...