Dominik Aschenbrenner
Overview
Explore the profile of Dominik Aschenbrenner including associated specialties, affiliations and a list of published articles.
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26
Citations
1118
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Recent Articles
1.
Thomas T, Friedrich M, Rich-Griffin C, Pohin M, Agarwal D, Pakpoor J, et al.
Nat Immunol
. 2024 Oct;
25(11):2152-2165.
PMID: 39438660
Precision medicine in immune-mediated inflammatory diseases (IMIDs) requires a cellular understanding of treatment response. We describe a therapeutic atlas for Crohn's disease (CD) and ulcerative colitis (UC) following adalimumab, an...
2.
Aschenbrenner D, Nassiri I, Venkateswaran S, Pandey S, Page M, Drowley L, et al.
Nat Commun
. 2024 May;
15(1):4529.
PMID: 38806456
Despite major advances in linking single genetic variants to single causal genes, the significance of genetic variation on transcript-level regulation of expression, transcript-specific functions, and relevance to human disease has...
3.
Latorre D, Monticelli S, Wypych T, Aschenbrenner D, Notarbartolo S
Front Immunol
. 2024 Mar;
15:1385415.
PMID: 38481997
No abstract available.
4.
Aschenbrenner D, Siegel R
Cell Rep Med
. 2023 Mar;
4(3):100983.
PMID: 36948149
Lilja et al. explore single-cell transcriptomes across multiple organs of mice with collagen-induced arthritis. They apply network analysis to prioritize functional pathways that support or suppress inflammation and integrate findings...
5.
Aschenbrenner D, Ye Z, Zhou Y, Hu W, Brooks I, Williams I, et al.
J Clin Immunol
. 2022 Nov;
43(2):495-511.
PMID: 36370291
Balancing natural selection is a process by which genetic variants arise in populations that are beneficial to heterozygous carriers, but pathogenic when homozygous. We systematically investigated the prevalence, structural, and...
6.
Cavounidis A, Pandey S, Capitani M, Friedrich M, Cross A, Gartner L, et al.
Mucosal Immunol
. 2022 Oct;
15(6):1431-1446.
PMID: 36302964
Hermansky-Pudlak syndrome (HPS) types 1 and 4 are caused by defective vesicle trafficking. The mechanism for Crohn's disease-like inflammation, lung fibrosis, and macrophage lipid accumulation in these patients remains enigmatic....
7.
Zhang F, Aschenbrenner D, Yoo J, Zuo T
Lancet Microbe
. 2022 Oct;
3(12):e969-e983.
PMID: 36182668
The gut mycobiome (fungi) is a small but crucial component of the gut microbiome in humans. Intestinal fungi regulate host homoeostasis, pathophysiological and physiological processes, and the assembly of the...
8.
Jansen J, Aschenbrenner D, Uhlig H, Coles M, Gaffney E
PLoS Comput Biol
. 2022 Jun;
18(6):e1010112.
PMID: 35731827
Cell-cell communication is mediated by many soluble mediators, including over 40 cytokines. Cytokines, e.g. TNF, IL1β, IL5, IL6, IL12 and IL23, represent important therapeutic targets in immune-mediated inflammatory diseases (IMIDs),...
9.
Wang L, Aschenbrenner D, Zeng Z, Cao X, Mayr D, Mehta M, et al.
Nat Genet
. 2022 Jan;
54(2):213.
PMID: 34987219
No abstract available.
10.
Bolton C, Smillie C, Pandey S, Elmentaite R, Wei G, Argmann C, et al.
Gastroenterology
. 2021 Nov;
162(3):859-876.
PMID: 34780721
Background & Aims: Monogenic forms of inflammatory bowel disease (IBD) illustrate the essential roles of individual genes in pathways and networks safeguarding immune tolerance and gut homeostasis. Methods: To build...