Dominik Aschenbrenner
Overview
Explore the profile of Dominik Aschenbrenner including associated specialties, affiliations and a list of published articles.
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26
Citations
1118
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Recent Articles
11.
Taylor H, Aschenbrenner D, Thomson M, Chen H, Uhlig H
J Clin Immunol
. 2021 Jul;
41(7):1701-1705.
PMID: 34269956
No abstract available.
12.
Wang L, Aschenbrenner D, Zeng Z, Cao X, Mayr D, Mehta M, et al.
Nat Genet
. 2021 Mar;
53(4):500-510.
PMID: 33782605
Spleen tyrosine kinase (SYK) is a critical immune signaling molecule and therapeutic target. We identified damaging monoallelic SYK variants in six patients with immune deficiency, multi-organ inflammatory disease such as...
13.
Aschenbrenner D, Quaranta M, Banerjee S, Ilott N, Jansen J, Steere B, et al.
Gut
. 2020 Oct;
70(6):1023-1036.
PMID: 33037057
Objective: Dysregulated immune responses are the cause of IBDs. Studies in mice and humans suggest a central role of interleukin (IL)-23-producing mononuclear phagocytes in disease pathogenesis. Mechanistic insights into the...
14.
Trzupek D, Dunstan M, Cutler A, Lee M, Godfrey L, Jarvis L, et al.
Genome Med
. 2020 Jun;
12(1):55.
PMID: 32580776
Background: Traditionally, the transcriptomic and proteomic characterisation of CD4 T cells at the single-cell level has been performed by two largely exclusive types of technologies: single-cell RNA sequencing (scRNA-seq) and...
15.
Schwerd T, Krause F, Twigg S, Aschenbrenner D, Chen Y, Borgmeyer U, et al.
Bone Res
. 2020 Jun;
8:24.
PMID: 32566365
The GP130 cytokine receptor subunit encoded by is the shared receptor for ten cytokines of the IL-6 family. We describe a homozygous non-synonymous variant in (p.R281Q) in a patient with...
16.
Beziat V, Tavernier S, Chen Y, Ma C, Materna M, Laurence A, et al.
J Exp Med
. 2020 Jun;
217(7).
PMID: 32516385
No abstract available.
17.
Beziat V, Tavernier S, Chen Y, Ma C, Materna M, Laurence A, et al.
J Exp Med
. 2020 Mar;
217(6).
PMID: 32207811
Autosomal dominant hyper-IgE syndrome (AD-HIES) is typically caused by dominant-negative (DN) STAT3 mutations. Patients suffer from cold staphylococcal lesions and mucocutaneous candidiasis, severe allergy, and skeletal abnormalities. We report 12...
18.
Chen Y, Grigelioniene G, Newton P, Gullander J, Elfving M, Hammarsjo A, et al.
J Exp Med
. 2020 Jan;
217(3).
PMID: 31914175
The gene IL6ST encodes GP130, the common signal transducer of the IL-6 cytokine family consisting of 10 cytokines. Previous studies have identified cytokine-selective IL6ST defects that preserve LIF signaling. We...
19.
Swan D, Aschenbrenner D, Lamb C, Chakraborty K, Clark J, Pandey S, et al.
Haematologica
. 2019 May;
104(10):e483-e486.
PMID: 31073077
No abstract available.
20.
Aschenbrenner D, Foglierini M, Jarrossay D, Hu D, Weiner H, Kuchroo V, et al.
Nat Immunol
. 2018 Nov;
20(1):109.
PMID: 30448856
In the version of this article initially published, in the legend to Fig. 1b, the description of the frequency of T17-IL-10 clones was incomplete for the first group; this should...