Dmitry M Korzhnev
Overview
Explore the profile of Dmitry M Korzhnev including associated specialties, affiliations and a list of published articles.
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76
Citations
2221
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Recent Articles
1.
Bregnard T, Bregnard T, Fairchild D, Chen X, Erlandsen H, Tarasov S, et al.
J Biol Chem
. 2025 Jan;
301(2):108149.
PMID: 39742997
Abnormalities in the expression of the ubiquitin ligase UBE3A (ubiquitin-protein ligase E3A)/E6AP (human papillomavirus E6-associated protein) are implicated in neurological disorders including Angelman syndrome and autism. Human UBE3A is expressed...
2.
Camilo-Ramos A, Korzhnev D, Pinheiro-Aguiar R, Almeida F
Biomol NMR Assign
. 2024 Oct;
18(2):257-262.
PMID: 39402262
The Rho GTPase (Ras homolog GTPases) system is a crucial signal transducer that regulates various cellular processes, including cell cycle and migration, genetic transcription, and apoptosis. In this study, we...
3.
Dash R, Arianna G, Patel S, Rizzo A, Harrahill N, Korzhnev D, et al.
Structure
. 2024 Oct;
32(11):2134-2146.e3.
PMID: 39366370
REV7 is a HORMA (Hop1, Rev7, Mad2) family adaptor protein best known as an accessory subunit of the translesion synthesis (TLS) DNA polymerase ζ (Polζ). In this role, REV7 binds...
4.
Mahdi S, Lim S, Bezsonova I, Beuning P, Korzhnev D
Biomol NMR Assign
. 2024 Sep;
18(2):293-297.
PMID: 39269602
The 81 kDa E. coli β clamp is a ring-shaped head-to-tail homodimer that encircles DNA and plays a central role in bacterial DNA replication by serving as a processivity factor...
5.
Arianna G, Korzhnev D
Genes (Basel)
. 2024 Jul;
15(7).
PMID: 39062611
Translesion synthesis (TLS) is a mechanism of DNA damage tolerance utilized by eukaryotic cells to replicate DNA across lesions that impede the high-fidelity replication machinery. In TLS, a series of...
6.
Zaino A, Dash R, James S, MacGilvary N, Crompton A, McPherson K, et al.
Bioorg Med Chem
. 2024 May;
106:117755.
PMID: 38749343
Translesion synthesis (TLS) is a cellular mechanism through which actively replicating cells recruit specialized, low-fidelity DNA polymerases to damaged DNA to allow for replication past these lesions. REV1 is one...
7.
MacDonald M, Wells N, Hassan B, Dudley J, Walters K, Korzhnev D, et al.
J Struct Biol
. 2024 Mar;
216(2):108082.
PMID: 38438058
While protein activity is traditionally studied with a major focus on the active site, the activity of enzymes has been hypothesized to be linked to the flexibility of adjacent regions,...
8.
Bregnard T, Fairchild D, Erlandsen H, Semenova I, Szczepaniak R, Ahmed A, et al.
Structure
. 2023 Jul;
31(9):1086-1099.e6.
PMID: 37473756
The promyelocytic leukemia protein, PML, plays a vital role in the cellular response to oxidative stress; however, the molecular mechanism of its action remains poorly understood. Here, we identify redox-sensitive...
9.
Arianna G, Geddes-Buehre D, Korzhnev D
Biomol NMR Assign
. 2023 May;
17(1):107-114.
PMID: 37129702
Rev7 is a versatile HORMA (Hop1, Rev7, Mad2) family adaptor protein with multiple roles in mitotic regulation and DNA damage response, and an essential accessory subunit of the translesion synthesis...
10.
Valles G, Jaiswal N, Korzhnev D, Bezsonova I
bioRxiv
. 2023 Jan;
PMID: 36711877
Ubiquitin-specific protease 7 (USP7) is a deubiquitinating enzyme responsible for the regulation of key human oncoproteins and tumor suppressors including Mdm2 and p53, respectively. Unlike other members of the USP...