Philipp Neudecker
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Explore the profile of Philipp Neudecker including associated specialties, affiliations and a list of published articles.
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48
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1115
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Recent Articles
1.
Leveille A, Schwarzrock T, Brown H, True B, Plasencia J, Neudecker P, et al.
ACS Med Chem Lett
. 2025 Feb;
16(2):271-277.
PMID: 39967642
We report the first structure-activity studies of arylidene-indolinone compound , which was reported as a ligand of autophagy-related protein LC3B. The literature has conflicting information on the binding affinity of...
2.
Leveille A, Schwarzrock T, Brown H, True B, Plasencia J, Neudecker P, et al.
bioRxiv
. 2024 Nov;
PMID: 39554136
We report the first structure-activity studies of arylidene-indolinone compound which was reported as a ligand of autophagy-related protein LC3B. The literature has conflicting information on the binding affinity of this...
3.
Becker N, Frieg B, Gremer L, Kupreichyk T, Gardon L, Freiburg P, et al.
J Am Chem Soc
. 2023 Jan;
145(4):2161-2169.
PMID: 36653015
Alzheimer's disease is a neurodegenerative disorder associated with the deposition of misfolded aggregates of the amyloid-β protein (Aβ). Aβ(1-42) is one of the most aggregation-prone components in senile plaques of...
4.
Konig A, Rosener N, Gremer L, Tusche M, Flender D, Reinartz E, et al.
J Biol Chem
. 2021 Mar;
296:100499.
PMID: 33667547
Human PrP (huPrP) is a high-affinity receptor for oligomeric amyloid β (Aβ) protein aggregates. Binding of Aβ oligomers to membrane-anchored huPrP has been suggested to trigger neurotoxic cell signaling in...
5.
Rosener N, Gremer L, Wordehoff M, Kupreichyk T, Etzkorn M, Neudecker P, et al.
Commun Biol
. 2020 Jul;
3(1):365.
PMID: 32647130
The interaction of prion protein (PrP) and α-synuclein (αSyn) oligomers causes synaptic impairment that might trigger Parkinson's disease and other synucleinopathies. Here, we report that αSyn oligomers (αSynO) cluster with...
6.
Mulnaes D, Porta N, Clemens R, Apanasenko I, Reiners J, Gremer L, et al.
J Chem Theory Comput
. 2020 Jan;
16(3):1953-1967.
PMID: 31967823
Knowledge of protein structures is essential to understand proteins' functions, evolution, dynamics, stabilities, and interactions and for data-driven protein- or drug design. Yet, experimental structure determination rates are far exceeded...
7.
Krichel C, Mockel C, Schillinger O, Huesgen P, Sticht H, Strodel B, et al.
Sci Rep
. 2019 Oct;
9(1):14167.
PMID: 31578424
(Macro-)autophagy is a compartmental degradation pathway conserved from yeast to mammals. The yeast protein Atg8 mediates membrane tethering/hemifusion and cargo recruitment and is essential for autophagy. The human MAP1LC3/GABARAP family...
8.
Stabinska J, Neudecker P, Ljimani A, Wittsack H, Lanzman R, Muller-Lutz A
Magn Reson Med
. 2019 Apr;
82(3):935-947.
PMID: 31004385
Purpose: To characterize the proton exchange in aqueous urea solutions using a modified version of the WEX II filter at high magnetic field, and to assess the feasibility of performing...
9.
Mockel C, Kubiak J, Schillinger O, Kuhnemuth R, Della Corte D, Schroder G, et al.
J Phys Chem B
. 2018 Dec;
123(7):1453-1480.
PMID: 30525615
Understanding the function of a protein requires not only knowledge of its tertiary structure but also an understanding of its conformational dynamics. Nuclear magnetic resonance (NMR) spectroscopy, polarization-resolved fluorescence spectroscopy...
10.
Dick M, Hartmann R, Weiergraber O, Bisterfeld C, Classen T, Schwarten M, et al.
Chem Sci
. 2018 Aug;
7(7):4492-4502.
PMID: 30155096
2-Deoxy-d-ribose-5-phosphate aldolase (DERA) is used in organic synthesis for the enantioselective reaction between acetaldehyde and a broad range of other aldehydes as acceptor molecules. Nevertheless, its application is hampered by...