Vladislav Yu Orekhov
Overview
Explore the profile of Vladislav Yu Orekhov including associated specialties, affiliations and a list of published articles.
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35
Citations
1154
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Recent Articles
1.
Agback T, Lesovoy D, Han X, Lomzov A, Sun R, Sandalova T, et al.
Commun Biol
. 2023 Nov;
6(1):1193.
PMID: 38001280
The dengue protease NS2B/NS3pro has been reported to adopt either an 'open' or a 'closed' conformation. We have developed a conformational filter that combines NMR with MD simulations to identify...
2.
Han X, Levkovets M, Lesovoy D, Sun R, Wallerstein J, Sandalova T, et al.
Biomol NMR Assign
. 2022 Sep;
16(2):363-371.
PMID: 36094731
Mucosa-associated lymphoid tissue protein 1 (MALT1) plays a key role in adaptive immune responses by modulating specific intracellular signalling pathways that control the development and proliferation of both T and...
3.
Agback P, Lesovoy D, Han X, Sun R, Sandalova T, Agback T, et al.
Biomol NMR Assign
. 2022 Feb;
16(1):135-145.
PMID: 35149939
The serotype II Dengue (DENV 2) virus is the most prevalent of all four known serotypes. Herein, we present nearly complete H, N, and C backbone and H, C isoleucine,...
4.
Kazimierczuk K, Kasprzak P, Georgoulia P, Matecko-Burmann I, Burmann B, Isaksson L, et al.
Chem Commun (Camb)
. 2020 Nov;
56(93):14585-14588.
PMID: 33146166
NMR spectroscopy is one of the basic tools for molecular structure elucidation. Unfortunately, the resolution of the spectra is often limited by inter-nuclear couplings. The existing workarounds often alleviate the...
5.
Agback P, Dominguez F, Pustovalova Y, Lukash T, Shiliaev N, Orekhov V, et al.
Virology
. 2019 Sep;
537:130-142.
PMID: 31493651
Alphavirus nsP3 proteins contain long, intrinsically disordered, hypervariable domains, HVD, which serve as hubs for interaction with many cellular proteins. Here, we have deciphered the mechanism and function of HVD...
6.
Pustovalova Y, Mayzel M, Orekhov V
Angew Chem Int Ed Engl
. 2018 Sep;
57(43):14043-14045.
PMID: 30175546
NMR studies of intrinsically disordered proteins and other complex biomolecular systems require spectra with the highest resolution and dimensionality. An efficient approach, extra-large NMR spectroscopy, is presented for experimental data...
7.
Marimon O, Teixeira J, Cordeiro T, Soo V, Wood T, Mayzel M, et al.
Nat Commun
. 2016 Dec;
7:13634.
PMID: 27929062
The Hha and TomB proteins from Escherichia coli form an oxygen-dependent toxin-antitoxin (TA) system. Here we show that YmoB, the Yersinia orthologue of TomB, and its single cysteine variant [C117S]YmoB...
8.
Hassanieh H, Mayzel M, Shi L, Katabi D, Orekhov V
J Biomol NMR
. 2015 Jul;
63(1):9-19.
PMID: 26123316
Increasing the dimensionality of NMR experiments strongly enhances the spectral resolution and provides invaluable direct information about atomic interactions. However, the price tag is high: long measurement times and heavy...
9.
Tikole S, Jaravine V, Orekhov V, Guntert P
PLoS One
. 2013 Jul;
8(7):e68567.
PMID: 23874675
Adequate digital resolution and signal sensitivity are two critical factors for protein structure determinations by solution NMR spectroscopy. The prime objective for obtaining high digital resolution is to resolve peak...
10.
Kazimierczuk K, Orekhov V
J Magn Reson
. 2012 Sep;
223:1-10.
PMID: 22960668
The resolution of multidimensional NMR spectra can be severely limited when regular sampling based on the Nyquist-Shannon theorem is used. The theorem binds the sampling rate with a bandwidth of...