Dhaval P Bhatt
Overview
Explore the profile of Dhaval P Bhatt including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
589
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Recent Articles
1.
LaPak K, Saeidi S, Bok I, Wamsley N, Plutzer I, Bhatt D, et al.
Sci Signal
. 2023 Dec;
16(815):eadi9018.
PMID: 38085818
The nuclear factor erythroid 2-related factor 2 (NRF2) transcription factor activates cytoprotective and metabolic gene expression in response to various electrophilic stressors. Constitutive NRF2 activity promotes cancer progression, whereas decreased...
2.
Speck S, Bhatt D, Zhang Q, Adak S, Yin L, Dong G, et al.
Cell Rep
. 2023 Nov;
42(11):113389.
PMID: 37925639
Acyl-protein thioesterases 1 and 2 (APT1 and APT2) reverse S-acylation, a potential regulator of systemic glucose metabolism in mammals. Palmitoylation proteomics in liver-specific knockout mice shows that APT1 predominates over...
3.
Agajanian M, Potjewyd F, Bowman B, Solomon S, LaPak K, Bhatt D, et al.
J Biol Chem
. 2022 Apr;
298(6):101986.
PMID: 35487243
Aberrant activation or suppression of WNT/β-catenin signaling contributes to cancer initiation and progression, neurodegeneration, and bone disease. However, despite great need and more than 40 years of research, targeted therapies...
4.
Bhatt D, Mills C, Anderson K, Henriques B, Lucas T, Francisco S, et al.
J Biol Chem
. 2022 Feb;
298(4):101723.
PMID: 35157847
A wide range of protein acyl modifications has been identified on enzymes across various metabolic processes; however, the impact of these modifications remains poorly understood. Protein glutarylation is a recently...
5.
Puray-Chavez M, LaPak K, Schrank T, Elliott J, Bhatt D, Agajanian M, et al.
Cell Rep
. 2021 Jul;
36(2):109364.
PMID: 34214467
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) variants govern transmissibility, responsiveness to vaccination, and disease severity. In a screen for new models of SARS-CoV-2 infection, we identify human...
6.
Hershberger K, Rooney J, Turner E, Donoghue L, Bodhicharla R, Maurer L, et al.
Redox Biol
. 2021 May;
43:102000.
PMID: 33993056
The consequences of damage to the mitochondrial genome (mtDNA) are poorly understood, although mtDNA is more susceptible to damage resulting from some genotoxicants than nuclear DNA (nucDNA), and many environmental...
7.
Puray-Chavez M, LaPak K, Schrank T, Elliott J, Bhatt D, Agajanian M, et al.
bioRxiv
. 2021 Mar;
PMID: 33688646
Established models for SARS-CoV-2 infection are limited and include cell lines of non-human origin and those engineered to overexpress ACE2, the cognate host cell receptor. We identified human H522 lung...
8.
Gonzalez-Hunt C, Luz A, Ryde I, Turner E, Ilkayeva O, Bhatt D, et al.
Toxicology
. 2020 Nov;
447:152630.
PMID: 33188857
Rotenone, a mitochondrial complex I inhibitor, has been widely used to study the effects of mitochondrial dysfunction on dopaminergic neurons in the context of Parkinson's disease. Although the deleterious effects...
9.
Mills C, Wang X, Bhatt D, Grimsrud P, Matson J, Lahiri D, et al.
Mol Cell Biol
. 2020 Nov;
41(2).
PMID: 33168699
The ubiquitin-proteasome system is essential for cell cycle progression. Cyclin F is a cell cycle-regulated substrate adapter F-box protein for the kp1, UL1, and -box protein (SCF) family of E3...
10.
Hibshman J, Doan A, Moore B, Kaplan R, Hung A, Webster A, et al.
Elife
. 2017 Oct;
6.
PMID: 29063832
/FoxO is required to survive starvation in , but how FoxO promotes starvation resistance is unclear. We show that /FoxO restructures carbohydrate metabolism by driving carbon flux through the glyoxylate...