Matthew D Hirschey
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Explore the profile of Matthew D Hirschey including associated specialties, affiliations and a list of published articles.
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82
Citations
8448
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Recent Articles
1.
Stewart A, Zachman D, Castellano-Escuder P, Kelly L, Zolyomi B, Aiduk M, et al.
bioRxiv
. 2025 Mar;
PMID: 40060603
Understanding how cellular pathways interact is crucial for treating complex diseases like cancer, yet our ability to map these connections systematically remains limited. Individual gene-gene interaction studies have provided insights...
2.
Keenan E, Bareja A, Lam Y, Grimsrud P, Hirschey M
bioRxiv
. 2024 Jun;
PMID: 38826225
Cysteine is a reactive amino acid central to the catalytic activities of many enzymes. It is also a common target of post-translational modifications (PTMs), such as palmitoylation. This longchain acyl...
3.
Sunassee E, Deutsch R, DAgostino V, Castellano-Escuder P, Siebeneck E, Ilkayeva O, et al.
Sci Adv
. 2024 Apr;
10(14):eadj7540.
PMID: 38579004
Fewer than 20% of triple-negative breast cancer patients experience long-term responses to mainstay chemotherapy. Resistant tumor subpopulations use alternative metabolic pathways to escape therapy, survive, and eventually recur. Here, we...
4.
Myakala K, Wang X, Shults N, Krawczyk E, Jones B, Yang X, et al.
J Biol Chem
. 2023 Jul;
299(8):104975.
PMID: 37429506
Diabetes mellitus is the leading cause of cardiovascular and renal disease in the United -States. Despite the beneficial interventions available for patients with diabetes, there remains a need for additional...
5.
Madonna M, Duer J, McKinney B, Sunassee E, Crouch B, Ilkayeva O, et al.
NPJ Breast Cancer
. 2022 Sep;
8(1):111.
PMID: 36163365
Recurrent cancer cells that evade therapy is a leading cause of death in breast cancer patients. This risk is high for women showing an overexpression of human epidermal growth factor...
6.
Trub A, Wagner G, Anderson K, Crown S, Zhang G, Thompson J, et al.
Nat Commun
. 2022 May;
13(1):2542.
PMID: 35538051
Statins are a class of drug widely prescribed for the prevention of cardiovascular disease, with pleiotropic cellular effects. Statins inhibit HMG-CoA reductase (HMGCR), which converts the metabolite HMG-CoA into mevalonate....
7.
Bhatt D, Mills C, Anderson K, Henriques B, Lucas T, Francisco S, et al.
J Biol Chem
. 2022 Feb;
298(4):101723.
PMID: 35157847
A wide range of protein acyl modifications has been identified on enzymes across various metabolic processes; however, the impact of these modifications remains poorly understood. Protein glutarylation is a recently...
8.
Hershberger K, Rooney J, Turner E, Donoghue L, Bodhicharla R, Maurer L, et al.
Redox Biol
. 2021 May;
43:102000.
PMID: 33993056
The consequences of damage to the mitochondrial genome (mtDNA) are poorly understood, although mtDNA is more susceptible to damage resulting from some genotoxicants than nuclear DNA (nucDNA), and many environmental...
9.
Keenan E, Zachman D, Hirschey M
Mol Cell
. 2021 Apr;
81(9):1868-1878.
PMID: 33798408
Protein modifications modulate nearly every aspect of cell biology in organisms, ranging from Archaea to Eukaryotes. The earliest evidence of covalent protein modifications was found in the early 20th century...
10.
Madonna M, Duer J, Lee J, Williams J, Avsaroglu B, Zhu C, et al.
Cancers (Basel)
. 2021 Jan;
13(1).
PMID: 33466329
Targeting a tumor's metabolic dependencies is a clinically actionable therapeutic approach; however, identifying subtypes of tumors likely to respond remains difficult. The use of lipids as a nutrient source is...