M Ben Major
Overview
Explore the profile of M Ben Major including associated specialties, affiliations and a list of published articles.
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Articles
25
Citations
293
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Recent Articles
1.
Choi W, Goldfarb D, Yan F, Major M, Fanning A, Peifer M
bioRxiv
. 2024 Nov;
PMID: 39574742
The network of proteins at the interface between cell-cell adherens junctions and the actomyosin cytoskeleton provides robust yet dynamic connections that facilitate cell shape change and motility. While this was...
2.
LaPak K, Saeidi S, Bok I, Wamsley N, Plutzer I, Bhatt D, et al.
Sci Signal
. 2023 Dec;
16(815):eadi9018.
PMID: 38085818
The nuclear factor erythroid 2-related factor 2 (NRF2) transcription factor activates cytoprotective and metabolic gene expression in response to various electrophilic stressors. Constitutive NRF2 activity promotes cancer progression, whereas decreased...
3.
Speck S, Bhatt D, Zhang Q, Adak S, Yin L, Dong G, et al.
Cell Rep
. 2023 Nov;
42(11):113389.
PMID: 37925639
Acyl-protein thioesterases 1 and 2 (APT1 and APT2) reverse S-acylation, a potential regulator of systemic glucose metabolism in mammals. Palmitoylation proteomics in liver-specific knockout mice shows that APT1 predominates over...
4.
Khan A, Metts J, Collins L, Mills C, Li K, Brademeyer A, et al.
bioRxiv
. 2023 Oct;
PMID: 37808753
Histone methyltransferases play essential roles in the organization and function of chromatin. They are also frequently mutated in human diseases including cancer. One such often mutated methyltransferase, SETD2, associates co-transcriptionally...
5.
Small molecule screen identifies pyrimethamine as an inhibitor of NRF2-driven esophageal hyperplasia
Paiboonrungruang C, Xiong Z, Lamson D, Li Y, Bowman B, Chembo J, et al.
Redox Biol
. 2023 Sep;
67:102901.
PMID: 37776708
Objective: NRF2 is a master transcription factor that regulates the stress response. NRF2 is frequently mutated and activated in human esophageal squamous cell carcinoma (ESCC), which drives resistance to chemotherapy...
6.
Chappell D, Sandhu P, Wong J, Bhatt A, Liu X, Buhrlage S, et al.
J Virol
. 2023 Mar;
97(3):e0176322.
PMID: 36995092
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi sarcoma (KS), the plasmablastic form of multicentric Castleman's disease, and primary effusion lymphoma. In sub-Saharan Africa, KS is the most...
7.
Hamad S, Montgomery S, Simon J, Bowman B, Spainhower K, Murphy R, et al.
Oncogene
. 2022 Aug;
41(39):4485.
PMID: 36002660
No abstract available.
8.
Hamad S, Montgomery S, Simon J, Bowman B, Spainhower K, Murphy R, et al.
Oncogene
. 2022 May;
41(25):3423-3432.
PMID: 35577980
Studies have shown that Nrf2 is one of the most common mutations found in human tumors. To elucidate how this genetic change contributes to lung cancer, we compared lung tumor...
9.
Sheth S, Farquhar D, Schrank T, Stepp W, Mazul A, Hayward M, et al.
Laryngoscope Investig Otolaryngol
. 2021 Aug;
6(4):699-707.
PMID: 34401494
Objectives: Patients with laryngeal squamous cell carcinoma (LSCC) often fail radiation therapy (RT), when received as monotherapy or in combination with other treatment modalities. Mechanisms for RT failure are poorly...
10.
Puray-Chavez M, LaPak K, Schrank T, Elliott J, Bhatt D, Agajanian M, et al.
Cell Rep
. 2021 Jul;
36(2):109364.
PMID: 34214467
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) variants govern transmissibility, responsiveness to vaccination, and disease severity. In a screen for new models of SARS-CoV-2 infection, we identify human...