Derek C Macallan
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Explore the profile of Derek C Macallan including associated specialties, affiliations and a list of published articles.
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53
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1669
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Recent Articles
21.
Westera L, Zhang Y, Tesselaar K, Borghans J, Macallan D
Methods Mol Biol
. 2013 Feb;
979:107-31.
PMID: 23397392
Humans have a remarkable ability to maintain relatively constant lymphocyte numbers across many decades, from puberty to old-age, despite a multitude of infectious and other challenges and a dramatic decline...
22.
Vukmanovic-Stejic M, Zhang Y, Akbar A, Macallan D
Methods Mol Biol
. 2011 Feb;
707:243-61.
PMID: 21287340
The in vivo proliferation and disappearance kinetics of lymphocytes may be estimated in humans from rates of deuterium-labeled glucose ((2)H(2)-glucose) incorporation into DNA. This protocol describes its application to regulatory...
23.
Planche T, Macallan D, Sobande T, Borrmann S, Kun J, Krishna S, et al.
Am J Physiol Regul Integr Comp Physiol
. 2010 Sep;
299(5):R1248-53.
PMID: 20811009
Previous epidemiological studies have demonstrated a protective association between the NOS2G-954C (NOS2(Lambaréné)) polymorphism in inducible nitric oxide synthase and severe malaria. The polymorphism is commoner in children with uncomplicated compared...
24.
Wallace D, Masters J, de Lara C, Henson S, Worth A, Zhang Y, et al.
Immunology
. 2010 Aug;
132(1):27-38.
PMID: 20738423
The immune response to human cytomegalovirus (HCMV) infection is characterized by the accumulation of HCMV-specific CD8(+) T cells, particularly in the elderly; such expansions may impair immune responses to other...
25.
In vivo ribosomal RNA turnover is down-regulated in leukaemic cells in chronic lymphocytic leukaemia
Defoiche J, Zhang Y, Lagneaux L, Willems L, Macallan D
Br J Haematol
. 2010 Aug;
151(2):192-5.
PMID: 20735396
No abstract available.
26.
Macallan D, Defoiche J, Willems L
Leuk Res
. 2010 May;
34(10):e273-4.
PMID: 20434772
No abstract available.
27.
Macallan D, Asquith B, Zhang Y, de Lara C, Ghattas H, Defoiche J, et al.
Nat Protoc
. 2009 Aug;
4(9):1313-27.
PMID: 19696750
Cell proliferation may be measured in vivo by quantifying DNA synthesis with isotopically labeled deoxyribonucleotide precursors. Deuterium-labeled glucose is one such precursor which, because it achieves high levels of enrichment...
28.
Defoiche J, Zhang Y, Lagneaux L, Pettengell R, Hegedus A, Willems L, et al.
Clin Chem
. 2009 Aug;
55(10):1824-33.
PMID: 19696118
Background: Most methods for estimation of rates of RNA production are not applicable in human in vivo clinical studies. We describe here an approach for measuring ribosomal RNA turnover in...
29.
Macallan D, Kent A, Holmes S, Farmer E, McCrorie P
Med Educ
. 2009 Aug;
43(8):799-807.
PMID: 19659494
Context: Problem-based learning (PBL) has been widely adopted in medical curricula for early-years training, but its use during clinical attachments has not been extensively explored. Objectives This study aimed to...
30.
Macallan D, Abaye D, Dottin S, Onanga M, Kombila M, Dzeing-Ella A, et al.
Rapid Commun Mass Spectrom
. 2009 Jul;
23(16):2467-75.
PMID: 19603467
Understanding blood volume changes in children with malaria is important for managing fluid status. Traditionally, blood/red cell volume measurements have used radioactive chromium isotopes. We applied an alternative approach, using...