Derek C Macallan
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Explore the profile of Derek C Macallan including associated specialties, affiliations and a list of published articles.
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53
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1669
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Recent Articles
11.
Boelen L, Debebe B, Silveira M, Salam A, Makinde J, Roberts C, et al.
Sci Immunol
. 2018 Nov;
3(29).
PMID: 30413420
Killer cell immunoglobulin-like receptors (KIRs) are expressed predominantly on natural killer cells, where they play a key role in the regulation of innate immune responses. Recent studies show that inhibitory...
12.
Diogo G, Sparrow A, Paul M, Copland A, Hart P, Stelter S, et al.
Cytokine
. 2017 Sep;
99:154-162.
PMID: 28917204
IL-4 is a pleiotropic cytokine that is highly Th2 polarizing. The ratio of IL-4 and its splice variant IL-4Δ2 observed in human health and disease suggests a role for both...
13.
Macallan D, Borghans J, Asquith B
Vaccines (Basel)
. 2017 Feb;
5(1).
PMID: 28165397
Long-term T cell-mediated protection depends upon the formation of a pool of memory cells to protect against future pathogen challenge. In this review we argue that looking at T cell...
14.
Ahmed R, Roger L, Costa Del Amo P, Miners K, Jones R, Boelen L, et al.
Cell Rep
. 2016 Dec;
17(11):2811-2818.
PMID: 27974195
Adaptive immunity requires the generation of memory T cells from naive precursors selected in the thymus. The key intermediaries in this process are stem cell-like memory T (T) cells, multipotent...
15.
Roychoudhuri R, Clever D, Li P, Wakabayashi Y, Quinn K, Klebanoff C, et al.
Nat Immunol
. 2016 May;
17(7):851-860.
PMID: 27158840
T cell antigen receptor (TCR) signaling drives distinct responses depending on the differentiation state and context of CD8(+) T cells. We hypothesized that access of signal-dependent transcription factors (TFs) to...
16.
Ahmed R, Westera L, Drylewicz J, Elemans M, Zhang Y, Kelly E, et al.
PLoS Comput Biol
. 2015 Oct;
11(10):e1004355.
PMID: 26437372
Stable isotope labeling is the state of the art technique for in vivo quantification of lymphocyte kinetics in humans. It has been central to a number of seminal studies, particularly...
17.
McCormick C, Francis A, Iliffe K, Webb H, Douch C, Pakianathan M, et al.
Front Immunol
. 2014 Nov;
5:507.
PMID: 25431572
Objectives: To investigate changing nutritional demographics of treated HIV-1-infected patients and explore causes of obesity, particularly in women of African origin. Methods: We prospectively reviewed nutritional demographics of clinic attenders...
18.
Hegedus A, Nyamweya S, Zhang Y, Govind S, Aspinall R, Mashanova A, et al.
J Infect Dis
. 2014 May;
210(5):752-61.
PMID: 24803534
Background: Many human immunodeficiency virus (HIV)-2-infected individuals remain aviremic and behave as long-term non-progressors but some progress to AIDS. We hypothesized that immune activation and T-cell turnover would be critical...
19.
Petrovas C, Yamamoto T, Price D, Rao S, Klatt N, Brenchley J, et al.
J Virol
. 2013 Jul;
87(17):9836-44.
PMID: 23824823
Programmed Death 1 (PD-1) expression by human/simian immunodeficiency virus (HIV/SIV)-specific CD8 T cells has been associated with defective cytokine production and reduced in vitro proliferation capacity. However, the cellular mechanisms...
20.
Nyamweya S, Hegedus A, Jaye A, Rowland-Jones S, Flanagan K, Macallan D
Rev Med Virol
. 2013 Feb;
23(4):221-40.
PMID: 23444290
HIV-1 and HIV-2 share many similarities including their basic gene arrangement, modes of transmission, intracellular replication pathways and clinical consequences: both result in AIDS. However, HIV-2 is characterised by lower...