Derek C Macallan
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Explore the profile of Derek C Macallan including associated specialties, affiliations and a list of published articles.
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1669
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Recent Articles
1.
Pearce J, Hadcocks L, Mansour S, van Zanten M, Jeffery S, Gordon K, et al.
Front Immunol
. 2023 Nov;
14:1279077.
PMID: 38022535
Introduction: The lymphatic system has a pivotal role in immune homeostasis. To better understand this, we investigated the impact of Primary Lymphatic Anomalies (PLA) on lymphocyte numbers and phenotype. Methods:...
2.
Zhang Y, Yan A, Boelen L, Hadcocks L, Salam A, Gispert D, et al.
J Clin Invest
. 2023 Apr;
133(12).
PMID: 37071474
BACKGROUNDThere is increasing evidence, in transgenic mice and in vitro, that inhibitory killer cell immunoglobulin-like receptors (iKIRs) can modulate T cell responses. Furthermore, we have previously shown that iKIRs are...
3.
Homerova I, Patel A, Macallan D
HIV Med
. 2022 Dec;
24(5):588-595.
PMID: 36457194
Objectives: Understanding how people living with HIV (PLWH) view antiretroviral therapy (ART) prescribing choices is fundamental to patient-centred care. We used the Desirability of Outcome Ranking (DOOR) approach to explore...
4.
Cuthill K, Zhang Y, Pepper A, Boelen L, Coulter E, Asquith B, et al.
Leukemia
. 2022 Jul;
36(9):2233-2241.
PMID: 35902732
Pathogenesis in chronic lymphocytic leukemia (CLL) is strongly linked to the potential for leukemic cells to migrate to and proliferate within lymph-nodes. Previous in vivo studies suggest that all leukemic...
5.
McNaughton A, Paton R, Edmans M, Youngs J, Wellens J, Phalora P, et al.
JCI Insight
. 2022 May;
7(13).
PMID: 35608920
The role of immune responses to previously seen endemic coronavirus epitopes in severe acute respiratory coronavirus 2 (SARS-CoV-2) infection and disease progression has not yet been determined. Here, we show...
6.
Youngs J, Provine N, Lim N, Sharpe H, Amini A, Chen Y, et al.
PLoS Pathog
. 2021 Sep;
17(9):e1009804.
PMID: 34529726
Prior studies have demonstrated that immunologic dysfunction underpins severe illness in COVID-19 patients, but have lacked an in-depth analysis of the immunologic drivers of death in the most critically ill...
7.
Ahmed R, Miners K, Lahoz-Beneytez J, Jones R, Roger L, Baboonian C, et al.
Cell Rep
. 2020 Dec;
33(11):108501.
PMID: 33326780
A central paradigm in the field of lymphocyte biology asserts that replicatively senescent memory T cells express the carbohydrate epitope CD57. These cells nonetheless accumulate with age and expand numerically...
8.
Staines H, Kirwan D, Clark D, Adams E, Augustin Y, Byrne R, et al.
Emerg Infect Dis
. 2020 Dec;
27(1).
PMID: 33256890
We investigated the dynamics of seroconversion in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. During March 29-May 22, 2020, we collected serum samples and associated clinical data from 177...
9.
Logan C, Mullender C, Mirfenderesky M, Feasey N, Cosgrove C, Riley P, et al.
J Infect
. 2020 Nov;
82(1):90-97.
PMID: 33137354
Objectives: Most data for Central Nervous System Tuberculosis (CNS-TB) derive from high-incidence, resource-limited countries. We sought to determine the presentation, management and outcomes of CNS-TB in a low-incidence setting with...
10.
Macallan D, Busch R, Asquith B
Curr Opin Syst Biol
. 2020 Jan;
18:77-86.
PMID: 31922055
Stable isotope labeling is a generally applicable method of quantifying cell dynamics. Its advent has opened up the way for the quantitative study of T cells in humans. However, the...