David V Hansen
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Explore the profile of David V Hansen including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Hansen D, Hanson J, Sheng M
J Cell Biol
. 2017 Dec;
217(2):459-472.
PMID: 29196460
Proliferation and activation of microglia in the brain, concentrated around amyloid plaques, is a prominent feature of Alzheimer's disease (AD). Human genetics data point to a key role for microglia...
12.
Chang M, Srinivasan K, Friedman B, Suto E, Modrusan Z, Lee W, et al.
J Exp Med
. 2017 Aug;
214(9):2611-2628.
PMID: 28778989
Loss-of-function mutations in cause frontotemporal dementia (FTD) with transactive response DNA-binding protein of 43 kD (TDP-43)-positive inclusions and neuronal ceroid lipofuscinosis (NCL). There are no disease-modifying therapies for either FTD...
13.
Yeh F, Hansen D, Sheng M
Trends Mol Med
. 2017 Apr;
23(6):512-533.
PMID: 28442216
Alzheimer's disease (AD) is the most common form of dementia and the 6th leading cause of death in the US. The neuropathological hallmarks of the disease are extracellular amyloid-β (Aβ)...
14.
Haddick P, Larson J, Rathore N, Bhangale T, Phung Q, Srinivasan K, et al.
J Alzheimers Dis
. 2017 Jan;
56(3):1037-1054.
PMID: 28106546
The common p.D358A variant (rs2228145) in IL-6R is associated with risk for multiple diseases and with increased levels of soluble IL-6R in the periphery and central nervous system (CNS). Here,...
15.
Erturk A, Mentz S, Stout E, Hedehus M, Dominguez S, Neumaier L, et al.
J Neurosci
. 2016 Sep;
36(38):9962-75.
PMID: 27656033
Unlabelled: After traumatic brain injury (TBI), neurons surviving the initial insult can undergo chronic (secondary) degeneration via poorly understood mechanisms, resulting in long-term cognitive impairment. Although a neuroinflammatory response is...
16.
Lee S, Le Pichon C, Adolfsson O, Gafner V, Pihlgren M, Lin H, et al.
Cell Rep
. 2016 Aug;
16(6):1690-1700.
PMID: 27475227
The spread of tau pathology correlates with cognitive decline in Alzheimer's disease. In vitro, tau antibodies can block cell-to-cell tau spreading. Although mechanisms of anti-tau function in vivo are unknown,...
17.
Srinivasan K, Friedman B, Larson J, Lauffer B, Goldstein L, Appling L, et al.
Nat Commun
. 2016 Apr;
7:11295.
PMID: 27097852
A common approach to understanding neurodegenerative disease is comparing gene expression in diseased versus healthy tissues. We illustrate that expression profiles derived from whole tissue RNA highly reflect the degenerating...
18.
Wetzel-Smith M, Hunkapiller J, Bhangale T, Srinivasan K, Maloney J, Atwal J, et al.
Nat Med
. 2014 Nov;
20(12):1452-7.
PMID: 25419706
We have identified a rare coding mutation, T835M (rs137875858), in the UNC5C netrin receptor gene that segregated with disease in an autosomal dominant pattern in two families enriched for late-onset...
19.
Hansen D, Lui J, Flandin P, Yoshikawa K, Rubenstein J, Alvarez-Buylla A, et al.
Nat Neurosci
. 2013 Oct;
16(11):1576-87.
PMID: 24097039
GABAergic cortical interneurons underlie the complexity of neural circuits and are particularly numerous and diverse in humans. In rodents, cortical interneurons originate in the subpallial ganglionic eminences, but their developmental...
20.
LaMonica B, Lui J, Hansen D, Kriegstein A
Nat Commun
. 2013 Apr;
4:1665.
PMID: 23575669
The human neocortex is increased in size and complexity as compared with most other species. Neocortical expansion has recently been attributed to protracted neurogenesis by outer radial glial cells in...