William J Meilandt
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Explore the profile of William J Meilandt including associated specialties, affiliations and a list of published articles.
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28
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1813
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Recent Articles
1.
Kahn O, Dominguez S, Glock C, Hayne M, Vito S, Sengupta Ghosh A, et al.
Cell Rep
. 2025 Mar;
44(3):115382.
PMID: 40056413
Neurofilament light chain (NfL) is a neuron-specific cytoskeletal protein that provides structural support for axons and is released into the extracellular space following neuronal injury. While NfL has been extensively...
2.
Schauer S, Cho C, Novikova G, Roth G, Lee J, Sharma A, et al.
Alzheimers Dement
. 2024 Aug;
20(9):5861-5888.
PMID: 39090679
Introduction: Triggering receptor expressed on myeloid cells 2 (TREM2) agonists are being clinically evaluated as disease-modifying therapeutics for Alzheimer's disease. Clinically translatable pharmacodynamic (PD) biomarkers are needed to confirm drug...
3.
Etxeberria A, Shen Y, Vito S, Silverman S, Imperio J, Lalehzadeh G, et al.
J Neurosci
. 2024 Jun;
44(29.
PMID: 38830764
Human genetics and preclinical studies have identified key contributions of TREM2 to several neurodegenerative conditions, inspiring efforts to modulate TREM2 therapeutically. Here, we characterize the activities of three TREM2 agonist...
4.
Dominguez S, Laufer B, Sengupta Ghosh A, Li Q, Ruggeri G, Emani M, et al.
iScience
. 2023 Nov;
26(11):108362.
PMID: 37965143
Heterozygous mutations in the granulin () gene are a leading cause of frontotemporal lobar degeneration with TDP-43 aggregates (FTLD-TDP). Polymorphisms in have been associated with disease risk in mutation carriers...
5.
Adrian M, Weber M, Tsai M, Glock C, Kahn O, Phu L, et al.
Nat Commun
. 2023 Oct;
14(1):6322.
PMID: 37813836
Microglial reactivity is a pathological hallmark in many neurodegenerative diseases. During stimulation, microglia undergo complex morphological changes, including loss of their characteristic ramified morphology, which is routinely used to detect...
6.
Zeng H, Huang J, Zhou H, Meilandt W, Dejanovic B, Zhou Y, et al.
Nat Neurosci
. 2023 Feb;
26(3):430-446.
PMID: 36732642
Complex diseases are characterized by spatiotemporal cellular and molecular changes that may be difficult to comprehensively capture. However, understanding the spatiotemporal dynamics underlying pathology can shed light on disease mechanisms...
7.
Sadekar S, Bowen M, Cai H, Jamalian S, Rafidi H, Shatz-Binder W, et al.
Clin Pharmacol Ther
. 2022 Jan;
111(4):826-834.
PMID: 35064573
Delivery of biologics via cerebrospinal fluid (CSF) has demonstrated potential to access the tissues of the central nervous system (CNS) by circumventing the blood-brain barrier and blood-CSF barrier. Developing an...
8.
Lee S, Rezzonico M, Friedman B, Huntley M, Meilandt W, Pandey S, et al.
Cell Rep
. 2021 Dec;
37(13):110158.
PMID: 34965428
Non-neuronal responses in neurodegenerative disease have received increasing attention as important contributors to disease pathogenesis and progression. Here we utilize single-cell RNA sequencing to broadly profile 13 cell types in...
9.
Lee S, Meilandt W, Xie L, Gandham V, Ngu H, Barck K, et al.
Neuron
. 2021 Mar;
109(8):1283-1301.e6.
PMID: 33675684
Loss-of-function TREM2 mutations strongly increase Alzheimer's disease (AD) risk. Trem2 deletion has revealed protective Trem2 functions in preclinical models of β-amyloidosis, a prominent feature of pre-diagnosis AD stages. How TREM2...
10.
Dominguez S, Earr T, Dourado M, Ngu H, Meilandt W, Hanson J
Sci Rep
. 2020 Sep;
10(1):15713.
PMID: 32973290
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron loss that ultimately leads to fatal paralysis. Reducing levels or function of the tyrosine kinase, ephrin type-A receptor...