David Sabatino
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Explore the profile of David Sabatino including associated specialties, affiliations and a list of published articles.
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35
Citations
194
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Recent Articles
11.
Cultrara C, Shah S, Antuono G, Heller C, Ramos J, Samuni U, et al.
Mol Ther Nucleic Acids
. 2019 Nov;
18:863-870.
PMID: 31739211
Oligoarginine sequences conjugated to a short cancer-targeting peptide (CTP) selective for the prostate-specific membrane antigen (PSMA) receptor was developed for selective small interfering RNA (siRNA) delivery to a human metastatic/castration-resistant...
12.
Cultrara C, Kozuch S, Ramasundaram P, Heller C, Shah S, Beck A, et al.
BMC Cancer
. 2018 Dec;
18(1):1263.
PMID: 30563499
Background: Glucose regulated protein 78 (GRP78) is a resident chaperone of the endoplasmic reticulum and a master regulator of the unfolded protein response under physiological and pathological cell stress conditions....
13.
Cultrara C, Shah S, Kozuch S, Patel M, Sabatino D
Chem Biol Drug Des
. 2018 Nov;
93(6):999-1010.
PMID: 30480355
New methods for the synthesis of higher-order siRNA motifs and their bioconjugates have recently gained widespread attention in the development of new and improved gene therapeutics. Our efforts aim to...
14.
Kozuch S, Cultrara C, Beck A, Heller C, Shah S, Patel M, et al.
ACS Omega
. 2018 Nov;
3(10):12975-12984.
PMID: 30411024
The integration of therapy and diagnostics, termed "theranostics", has recently gained widespread utility in the development of new and improved therapeutics that effectively diagnose and treat diseases, such as cancer....
15.
Shah S, Cultrara C, Kozuch S, Patel M, Ramos J, Samuni U, et al.
Bioconjug Chem
. 2018 Sep;
29(11):3638-3648.
PMID: 30235926
The emerging field of RNAi nanotechnology has led to rapid advances in the applications of siRNAs in chemical biology, medicinal chemistry, and biotechnology. In our RNAi approach, bioconjugation of linear,...
16.
Rana N, Cultrara C, Phillips M, Sabatino D
Bioorg Med Chem Lett
. 2017 Aug;
27(17):4019-4023.
PMID: 28789897
In the search for more potent peptide-based anti-cancer conjugates the generation of new, functionally diverse nucleolipid derived D-(KLAKLAK)-AK sequences has enabled a structure and anti-cancer activity relationship study. A reductive...
17.
Carrion E, Santiago J, Sabatino D, Gorun S
Inorg Chem
. 2017 May;
56(12):7210-7216.
PMID: 28541049
The functionalized, asymmetric fluoro-fluoroalkyl scaffold FHCOOHPcZn (3) was used to prepare FHCOOPcZn-6-amino-hexanoate-CTVALPGGYVRVC (5), a Pep42 peptide bioconjugate envisioned for photodynamic therapy, which can specifically target the GRP78 chaperone protein overexpressed...
18.
Patel M, Kozuch S, Cultrara C, Yadav R, Huang S, Samuni U, et al.
Nano Lett
. 2016 Sep;
16(10):6099-6108.
PMID: 27669096
The emerging field of RNA nanotechnology has been used to design well-programmed, self-assembled nanostructures for applications in chemistry, biology, and medicine. At the forefront of its utility in cancer is...
19.
Rana N, Huang S, Patel P, Samuni U, Sabatino D
Bioorg Med Chem Lett
. 2016 Jun;
26(15):3567-71.
PMID: 27329798
The synthesis, characterization and anti-cancer activity of a novel peptide nucleolipid bioconjugate is reported in this study. The prerequisite 5'-carboxy derived nucleolipid was synthesized following a five-step solution-phase approach and...
20.
Phillips M, Romeo F, Bitsaktsis C, Sabatino D
Biopolymers
. 2016 May;
106(5):658-72.
PMID: 27216712
The rise of biologics that can stimulate immune responses towards the eradication of tumors has led to the evolution of cancer-based immunotherapy. Representatively, B7H6 has been recently identified as a...