Caroline Proulx
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Explore the profile of Caroline Proulx including associated specialties, affiliations and a list of published articles.
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52
Citations
990
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Recent Articles
1.
Bowles M, Willis E, Trombley M, Chen C, Proulx C
J Am Chem Soc
. 2025 Jan;
147(2):1404-1410.
PMID: 39761202
We present the first approach to controlled metal chelation of peptide backbones, where the anchoring site is an aza-amino acid nitrogen and the directionality of chelation events is dictated by...
2.
Galiakhmetov A, Shah A, Lane A, Davern C, Proulx C, Nevzorov A
J Struct Biol X
. 2023 Dec;
9:100095.
PMID: 38094992
Solid-state Nuclear Magnetic Resonance (NMR) in combination with magnetically aligned discoidal lipid mimics allows for studying the conformations of membrane proteins in planar, lipid-rich bilayer environments and at the physiological...
3.
Late-Stage Chloride Displacements Enable Access to Peptoids with -Inducing Alkylammonium Side Chains
Davern C, Proulx C
Org Lett
. 2023 Aug;
25(33):6195-6199.
PMID: 37578853
The synthesis of peptoids possessing multiple -inducing monomers with alkylammonium side chains is reported, where chloropropyl side chains are diversified on a solid support by late-stage S2 displacements with amines....
4.
5.
Galiakhmetov A, Davern C, Esteves R, Awosanya E, Guthrie Q, Proulx C, et al.
Biophys J
. 2022 Aug;
121(17):3263-3270.
PMID: 35918898
Development of a robust, uniform, and magnetically orientable lipid mimetic will undoubtedly advance solid-state NMR of macroscopically aligned membrane proteins. Here, we report on a novel lipid membrane mimetic based...
6.
Young H, Proulx C
Org Biomol Chem
. 2022 May;
20(31):6245-6249.
PMID: 35616496
A late-stage α-C-H functionalization reaction of resin-bound, electron-rich -aryl peptides with boronic acid nucleophiles under mild conditions is reported. We explore the impact of the -arylglycinyl peptide structure on reactivity,...
7.
Proulx C, Dumais Y, Beauchamp G, Steagall P
J Vet Dent
. 2022 Mar;
39(2):133-141.
PMID: 35257623
The aim of this study was to evaluate the reliability of electric pulp test (EPT), cold pulp test (CPT) and tooth transillumination (TTI) in the assessment of pulpal health in...
8.
Bowles M, Proulx C
Org Lett
. 2022 Feb;
24(9):1768-1773.
PMID: 35226505
Azapeptides undergo on-resin, late-stage -alkylations to install side chains with high chemoselectivity for the hydrazide nitrogen atoms. The major product is the N1-alkylated "azapeptoid", with only small amounts (<10%) of...
9.
Bowles M, Proulx C
Methods Enzymol
. 2021 Jul;
656:169-190.
PMID: 34325786
Azapeptides contain at least one aza-amino acid, where the α-carbon has been replaced by a nitrogen atom, and have found broad applicability in fields ranging from medicinal chemistry to biomaterials....
10.
Davern C, Lowe B, Rosfi A, Ison E, Proulx C
Chem Sci
. 2021 Jul;
12(24):8401-8410.
PMID: 34221321
The use of hydrazones as a new type of submonomer in peptoid synthesis is described, giving access to peptoid monomers that are structure-inducing. A wide range of hydrazones were found...