David M Ferguson
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Explore the profile of David M Ferguson including associated specialties, affiliations and a list of published articles.
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41
Citations
565
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Recent Articles
1.
Liao E, Yang M, Kochen N, Vunnam N, Braun A, Ferguson D, et al.
Mol Neurobiol
. 2023 Jul;
60(10):6133-6144.
PMID: 37428404
Proteasomal degradation of intrinsically disordered proteins, such as tau, is a critical component of proteostasis in both aging and neurodegenerative diseases. In this study, we investigated proteasomal activation by MK886...
2.
Vunnam N, Yang M, Lo C, Paulson C, Fiers W, Huber E, et al.
ACS Bio Med Chem Au
. 2023 Jun;
3(3):270-282.
PMID: 37363080
Tumor necrosis factor (TNF) plays an important role in the pathogenesis of inflammatory and autoimmune diseases such as rheumatoid arthritis and Crohn's disease. The biological effects of TNF are mediated...
3.
Escalante D, Aldrich C, Ferguson D
Molecules
. 2022 May;
27(9).
PMID: 35565967
Molecular mechanics force field calculations have historically shown significant limitations in modeling the energetic and conformational interconversions of highly substituted furanose rings. This is primarily due to the gauche effect...
4.
Yang M, Larson P, Brown L, Schultz J, Kucaba T, Griffith T, et al.
Bioorg Med Chem Lett
. 2022 Jan;
59:128548.
PMID: 35051578
Toll-like receptors (TLRs) 7 and 8 are key targets in the development of immunomodulatory drugs for treating infectious disease, cancer, and autoimmune disorders. These receptors can adopt both agonist and...
5.
Escalante D, Ferguson D
Med Chem Res
. 2021 Feb;
30(2):399-409.
PMID: 33564221
The type II transmembrane serine protease TMPRSS2 facilitates the entry of coronaviruses, such as SARS-CoV-2, into host cells by cleaving the S/S interface of the viral spike protein. Based on...
6.
Kim H, Khanna V, Kucaba T, Zhang W, Sehgal D, Ferguson D, et al.
Mol Pharm
. 2020 May;
17(6):2109-2124.
PMID: 32383885
Activated natural killer (NK) cells can kill malignant tumor cells via granule exocytosis and secretion of IFN-γ, a key regulator of the TH1 response. Thus, mobilization of NK cells can...
7.
Wang X, Zeng Y, Sheng L, Larson P, Liu X, Zou X, et al.
J Med Chem
. 2019 Feb;
62(5):2305-2332.
PMID: 30779564
Optochin, a cinchona alkaloid derivative discovered over 100 years ago, possesses highly selective antibacterial activity toward Streptococcus pneumoniae. Pneumococcal disease remains the leading source of bacterial pneumonia and meningitis worldwide....
8.
Bockman M, Engelhart C, Cramer J, Howe M, Mishra N, Zimmerman M, et al.
ACS Infect Dis
. 2019 Jan;
5(4):598-617.
PMID: 30652474
The synthesis, absolute stereochemical configuration, complete biological characterization, mechanism of action and resistance, and pharmacokinetic properties of ( S)-(-)-acidomycin are described. Acidomycin possesses promising antitubercular activity against a series of...
9.
Kim H, Khanna V, Kucaba T, Zhang W, Ferguson D, Griffith T, et al.
Mol Pharm
. 2019 Jan;
16(3):1200-1210.
PMID: 30620878
Cancer vaccines composed of tumor-associated antigens (TAAs) and toll-like receptor (TLR) agonists have shown promising antitumor efficacy in preclinical studies by generating antigen-specific CD8 T cells, but translation of cancer...
10.
Kim H, Sehgal D, Kucaba T, Ferguson D, Griffith T, Panyam J
Nanoscale
. 2018 Nov;
10(44):20851-20862.
PMID: 30403212
Synthetic imidazoquinoline-based toll-like receptor (TLR) 7/8 bi-specific agonists are promising vaccine adjuvants that can induce maturation of dendritic cells (DCs) and activate them to secrete pro-inflammatory cytokines. However, in vivo...