Tamara A Kucaba
Overview
Explore the profile of Tamara A Kucaba including associated specialties, affiliations and a list of published articles.
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35
Citations
745
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Recent Articles
1.
Price A, Becker E, Barrios E, Mazer M, McGonagill P, Bergmann C, et al.
Front Immunol
. 2024 Oct;
15:1418613.
PMID: 39469706
Introduction: Sepsis is a complex clinical syndrome characterized by a heterogenous host immune response. Historically, static protein and transcriptomic metrics have been employed to describe the underlying biology. Here, we...
2.
Ungaro R, Xu J, Kucaba T, Rao M, Bergmann C, Brakenridge S, et al.
J Immunol Methods
. 2024 Aug;
533:113743.
PMID: 39147231
Sepsis remains a leading cause of death worldwide with no proven immunomodulatory therapies. Stratifying Patient Immune Endotypes in Sepsis ('SPIES') is a prospective, multicenter observational study testing the utility of...
3.
Martin M, Skon-Hegg C, Kim C, Xu J, Kucaba T, Swanson W, et al.
Cell Rep
. 2023 Dec;
42(11).
PMID: 38111515
Uropathogenic . (UPEC) is a primary organism responsible for urinary tract infections and a common cause of sepsis. Microbially experienced laboratory mice, generated by cohousing with pet store mice, exhibit...
4.
Barrios E, Mazer M, McGonagill P, Bergmann C, Goodman M, Gould R, et al.
JCI Insight
. 2023 Dec;
9(2).
PMID: 38100268
BACKGROUNDSepsis remains a major clinical challenge for which successful treatment requires greater precision in identifying patients at increased risk of adverse outcomes requiring different therapeutic approaches. Predicting clinical outcomes and...
5.
Barrios E, Mazer M, McGonagill P, Bergmann C, Goodman M, Gould R, et al.
medRxiv
. 2023 Sep;
PMID: 37745385
Background: Sepsis remains a major clinical challenge for which successful treatment requires greater precision in identifying patients at increased risk of adverse outcomes requiring different therapeutic approaches. Predicting clinical outcomes...
6.
Burger S, Stenger T, Pierson M, Sridhar A, Huggins M, Kucaba T, et al.
J Immunol
. 2023 Apr;
210(11):1740-1751.
PMID: 37074206
Microbial experience fundamentally shapes immunity, particularly during the perinatal period when the immune system is underdeveloped, and novel microbial encounters are common. Most animal models are raised in specific pathogen-free...
7.
Sjaastad F, Huggins M, Lucas E, Skon-Hegg C, Swanson W, Martin M, et al.
J Immunol
. 2022 Nov;
209(11):2149-2159.
PMID: 36426978
Successful vaccination strategies offer the potential for lifelong immunity against infectious diseases and cancer. There has been increased attention regarding the limited translation of some preclinical findings generated using specific...
8.
Block K, Iijima K, Pierson M, Walsh D, Tei R, Kucaba T, et al.
Nat Immunol
. 2022 Nov;
23(12):1703-1713.
PMID: 36411381
Lung group 2 innate lymphoid cells (ILC2s) control the nature of immune responses to airway allergens. Some microbial products, including those that stimulate interferons, block ILC2 activation, but whether this...
9.
Yang M, Larson P, Brown L, Schultz J, Kucaba T, Griffith T, et al.
Bioorg Med Chem Lett
. 2022 Jan;
59:128548.
PMID: 35051578
Toll-like receptors (TLRs) 7 and 8 are key targets in the development of immunomodulatory drugs for treating infectious disease, cancer, and autoimmune disorders. These receptors can adopt both agonist and...
10.
Sjaastad F, Kucaba T, Dileepan T, Swanson W, Dail C, Cabrera-Perez J, et al.
Front Immunol
. 2020 Sep;
11:1786.
PMID: 32903436
Patients who survive sepsis display prolonged immune dysfunction and heightened risk of secondary infection. CD4 T cells support a variety of cells required for protective immunity, and perturbations to the...