David L Williams
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Explore the profile of David L Williams including associated specialties, affiliations and a list of published articles.
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331
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11714
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Recent Articles
1.
Kintner J, Callaghan M, Bulawa L, Chu A, Ma Z, Williams D, et al.
Pathog Dis
. 2025 Jan;
83.
PMID: 39886876
Chlamydia trachomatis and Candida albicans are common inhabitants of the female genital tract. Candida albicans can impact the viability and pathogenesis of some bacteria. Previously, we investigated physical interactions between...
2.
Hao D, Caja K, McBride M, Owen A, Bohannon J, Hernandez A, et al.
J Leukoc Biol
. 2024 Dec;
PMID: 39722231
Aging significantly increases the incidence and severity of infections, with individuals aged 65 and above accounting for 65% of sepsis cases. Innate immune training, known as "trained immunity" or "innate...
3.
Flowers B, Rullo A, Zhang A, Chang K, Petukhova V, Aboagye S, et al.
Free Radic Biol Med
. 2024 Dec;
227():201-209.
PMID: 39643141
Mounting evidence shows that tumor growth and progression rely on thioredoxin reductase 1 (TXNRD1)-mediated detoxification of oxidative stress that results from deregulated metabolism and mitogenic signaling in tumors. TXNRD1 levels...
4.
Ma Z, Ensley H, Lowman D, Kruppa M, Williams D
Carbohydr Res
. 2024 Nov;
547:109325.
PMID: 39603178
Fungal mannans are located on the exterior of the fungal cell wall, where they interact with the environment and, ultimately, the human host. Mannans play a major role in shaping...
5.
Cesar-Rodo E, Dupouy B, Haberli C, Strub J, Williams D, Maser P, et al.
Molecules
. 2024 Nov;
29(22).
PMID: 39598657
Ψ-1,4-naphthoquinones (Ψ-NQ) are non-quinoid compounds in which aromaticity-found in 1,4-naphthoquinones-is broken by the introduction of an angular methyl at C-4a or -8a. This series was designed to act as prodrugs...
6.
Lim K, Amrute J, Kovacs A, Diwan A, Williams D, Mann D
bioRxiv
. 2024 Oct;
PMID: 39386701
Background: Although the ability of the heart to adapt to environmental stress has been studied extensively, the molecular and cellular mechanisms responsible for cardioprotection are not yet fully understood. Methods:...
7.
Zhang T, Chen L, Kueth G, Shao E, Wang X, Ha T, et al.
Front Immunol
. 2024 Oct;
15:1483400.
PMID: 39372401
Lactate significantly impacts immune cell function in sepsis and septic shock, transcending its traditional view as just a metabolic byproduct. This review summarizes the role of lactate as a biomarker...
8.
Miao J, Williams D, Kruppa M, Peters B
mSphere
. 2024 Sep;
9(10):e0057524.
PMID: 39315809
To adapt to various host microenvironments, the human fungal pathogen possesses the capacity to accumulate and store glycogen as an internal carbohydrate source. In the model yeast , Glc7p and...
9.
Ardini M, Aboagye S, Petukhova V, Kastrati I, Ippoliti R, Thatcher G, et al.
J Med Chem
. 2024 Sep;
67(18):15947-15967.
PMID: 39250602
Pyridine nucleotide-disulfide oxidoreductases are underexplored as drug targets, and thioredoxin reductases (TrxRs) stand out as compelling pharmacological targets. Selective TrxR inhibition is challenging primarily due to the reliance on covalent...
10.
Dos Santos J, Moreno M, Teufel L, Chilibroste S, Keating S, Groh L, et al.
Cell Rep
. 2024 Mar;
43(3):113932.
PMID: 38457336
Innate immune cells can undergo long-term functional reprogramming after certain infections, a process called trained immunity (TI). Here, we focus on antigens of Leishmania braziliensis, which induced anti-tumor effects via...