Tuanzhu Ha
Overview
Explore the profile of Tuanzhu Ha including associated specialties, affiliations and a list of published articles.
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80
Citations
2776
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Recent Articles
1.
Zhang T, Chen L, Kueth G, Shao E, Wang X, Ha T, et al.
Front Immunol
. 2024 Oct;
15:1483400.
PMID: 39372401
Lactate significantly impacts immune cell function in sepsis and septic shock, transcending its traditional view as just a metabolic byproduct. This review summarizes the role of lactate as a biomarker...
2.
Chen H, Hou Y, Zhai Y, Yang J, Que L, Liu J, et al.
J Leukoc Biol
. 2023 Feb;
113(2):95-108.
PMID: 36822176
The polarization of macrophages to the M1 or M2 phenotype has a pivotal role in inflammatory response following myocardial ischemia/reperfusion injury. Peli1, an E3 ubiquitin ligase, is closely associated with...
3.
Fan M, Yang K, Wang X, Chen L, Gill P, Ha T, et al.
Sci Adv
. 2023 Feb;
9(5):eadc9465.
PMID: 36735787
High levels of lactate are positively associated with the prognosis and mortality in patients with heart attack. Endothelial-to-mesenchymal transition (EndoMT) plays an important role in cardiac fibrosis. Here, we report...
4.
Fan M, Yang K, Wang X, Zhang X, Xu J, Tu F, et al.
Shock
. 2022 Oct;
58(4):304-312.
PMID: 36256626
Introduction: Sepsis impaired vascular integrity results in multiple organ failure. Circulating lactate level is positively correlated with sepsis-induced mortality. We investigated whether lactate plays a role in causing endothelial barrier...
5.
Yang J, Tong T, Zhu C, Zhou M, Jiang Y, Chen H, et al.
J Mol Cell Cardiol
. 2022 Sep;
173:30-46.
PMID: 36179399
Autophagy flux is impaired during myocardial ischemia/reperfusion (M-I/R) via the accumulation of autophagosome and insufficient clearance, which exacerbates cardiomyocyte death. Peli1 (Pellion1) is a RING finger domain-containing ubiquitin E3 ligase...
6.
Yang K, Fan M, Wang X, Xu J, Wang Y, Gill P, et al.
Sci Adv
. 2022 Apr;
8(17):eabm8965.
PMID: 35476437
Circulating lactate levels are a critical biomarker for sepsis and are positively correlated with sepsis-associated mortality. We investigated whether lactate plays a biological role in causing endothelial barrier dysfunction in...
7.
Yang K, Holt M, Fan M, Lam V, Yang Y, Ha T, et al.
Front Immunol
. 2022 Apr;
13:868679.
PMID: 35401579
Coronavirus disease 2019 (COVID-19), an infectious respiratory disease propagated by a new virus known as Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has resulted in global healthcare crises. Emerging evidence from...
8.
Yang K, Fan M, Wang X, Xu J, Wang Y, Tu F, et al.
Cell Death Differ
. 2021 Aug;
29(1):133-146.
PMID: 34363018
High circulating levels of lactate and high mobility group box-1 (HMGB1) are associated with the severity and mortality of sepsis. However, it is unclear whether lactate could promote HMGB1 release...
9.
Yang K, Xu J, Fan M, Tu F, Wang X, Ha T, et al.
Front Immunol
. 2020 Oct;
11:587913.
PMID: 33123172
Recent evidence from cancer research indicates that lactate exerts a suppressive effect on innate immune responses in cancer. This study investigated the mechanisms by which lactate suppresses macrophage pro-inflammatory responses....
10.
Fan M, Yang K, Wang X, Wang Y, Tu F, Ha T, et al.
JCI Insight
. 2020 Aug;
5(18).
PMID: 32790647
Angiogenesis is essential for cardiac functional recovery after myocardial infarction (MI). HSPA12B is predominately expressed in endothelial cells and required for angiogenesis. Yes-associated protein (YAP) plays an important role in...