Siamon Gordon
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Explore the profile of Siamon Gordon including associated specialties, affiliations and a list of published articles.
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239
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30303
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Recent Articles
1.
Ojwach D, Annels N, Sunshine S, Simpkin D, Duruanyanwu J, Webber T, et al.
bioRxiv
. 2024 Nov;
PMID: 39554009
We previously showed a link between maternal vascular malperfusion and pre-term birth (PTB) in pregnant people living with HIV (PPLH) initiating antiretroviral treatment (ART) before pregnancy, indicating poor placental vascularisation....
2.
Graham C, Gordon S, Kubes P
Cell Tissue Res
. 2024 Oct;
PMID: 39392500
The Kupffer cell was first discovered by Karl Wilhelm von Kupffer in 1876, labeling them as "Sternzellen." Since their discovery as the primary macrophages of the liver, researchers have gradually...
3.
Gordon S, Roberti A, Kaufmann S
Cells
. 2024 Aug;
13(16).
PMID: 39195266
The mononuclear phagocyte system includes monocytes, macrophages, some dendritic cells, and multinuclear giant cells. These cell populations display marked heterogeneity depending on their differentiation from embryonic and bone marrow hematopoietic...
4.
Orsenigo F, Stewart A, Hammer C, Clarke E, Simpkin D, Attia H, et al.
Cell Rep
. 2024 Jun;
43(6):114352.
PMID: 38870011
Addressing the mononuclear phagocyte system (MPS) and macrophage M1/M2 activation is important in diagnosing hematological disorders and inflammatory pathologies and designing therapeutic tools. CSF1R is a reliable marker to identify...
5.
Onyishi C, Jeon Y, Fejer G, Mukhopadhyay S, Gordon S, May R
Eur J Immunol
. 2024 Mar;
54(6):e2350771.
PMID: 38494423
Vomocytosis, also known as nonlytic exocytosis, is a process whereby fully phagocytosed microbes are expelled from phagocytes without discernible damage to either the phagocyte or microbe. Although this phenomenon was...
6.
Onyishi C, Desanti G, Wilkinson A, Lara-Reyna S, Frickel E, Fejer G, et al.
Nat Commun
. 2023 Aug;
14(1):4895.
PMID: 37580395
The opportunistic fungal pathogen Cryptococcus neoformans causes lethal infections in immunocompromised patients. Macrophages are central to the host response to cryptococci; however, it is unclear how C. neoformans is recognised...
7.
Henderson S, Horsley H, Frankel P, Khosravi M, Goble T, Carter S, et al.
Ann Rheum Dis
. 2023 Feb;
82(6):848-856.
PMID: 36801813
Objectives: Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are autoimmune vasculitides associated with antineutrophil cytoplasm antibodies that target proteinase 3 (PR3) or myeloperoxidase (MPO) found within neutrophils and monocytes....
8.
Paolicelli R, Sierra A, Stevens B, Tremblay M, Aguzzi A, Ajami B, et al.
Neuron
. 2022 Nov;
110(21):3458-3483.
PMID: 36327895
Microglial research has advanced considerably in recent decades yet has been constrained by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." This dualistic classification...
9.
Chu T, Zheng-Gerard C, Huang K, Chang Y, Chen Y, I K, et al.
Nat Commun
. 2022 Oct;
13(1):6385.
PMID: 36302784
Neutrophils play essential anti-microbial and inflammatory roles in host defense, however, their activities require tight regulation as dysfunction often leads to detrimental inflammatory and autoimmune diseases. Here we show that...
10.
Combes T, Orsenigo F, Stewart A, Mendis A, Dunn-Walters D, Gordon S, et al.
Immunother Adv
. 2022 Aug;
1(1):ltab003.
PMID: 35915730
Mononuclear phagocytes defend tissues, present antigens, and mediate recovery and healing. To date, we lack a marker to unify mononuclear phagocytes in humans or that informs us about their origin....