David J Wang
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Explore the profile of David J Wang including associated specialties, affiliations and a list of published articles.
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22
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405
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Recent Articles
1.
Pryce B, Oles A, Talbert E, Romeo M, Vaena S, Sharma S, et al.
Cell Rep
. 2024 Oct;
43(11):114925.
PMID: 39475511
Although cancer cachexia is classically characterized as a systemic inflammatory disorder, emerging evidence indicates that weight loss also associates with local tissue inflammation. We queried the regulation of this inflammation...
2.
Spadafora V, Pryce B, Oles A, Talbert E, Romeo M, Vaena S, et al.
BMC Cancer
. 2024 Apr;
24(1):414.
PMID: 38570770
Background: Pancreatic ductal adenocarcinoma (PDAC) presents with a high mortality rate. Two important features of PDAC contribute to this poor outcome. The first is metastasis which occurs in ~ 80%...
3.
Gao X, Wu Y, Chick J, Abbott A, Jiang B, Wang D, et al.
Cell Rep
. 2023 Mar;
42(4):112314.
PMID: 37000627
Elucidating the mechanisms of resistance to immunotherapy and developing strategies to improve its efficacy are challenging goals. Bioinformatics analysis demonstrates that high CDK6 expression in melanoma is associated with poor...
4.
Pryce B, Wang D, Zimmers T, Ostrowski M, Guttridge D
Cancer Cell
. 2023 Mar;
41(3):581-584.
PMID: 36868225
Advanced cancers often present with the cachexia syndrome that impacts peripheral tissues, leading to involuntary weight loss and reduced prognosis. The central tissues undergoing depletion are skeletal muscle and adipose,...
5.
Wang D, Song P, Nault K
Am J Health Syst Pharm
. 2021 Dec;
79(8):636-642.
PMID: 34874991
Purpose: Inadequate pain control after cardiac surgery increases postoperative morbidity. Increasing evidence suggests that perioperative intravenous (IV) methadone results in improved analgesia. This study evaluated the effect of intraoperative IV...
6.
Pitarresi J, Liu X, Avendano A, Thies K, Sizemore G, Hammer A, et al.
Life Sci Alliance
. 2018 Nov;
1(5):e201800190.
PMID: 30456390
The contribution of the tumor microenvironment to pancreatic ductal adenocarcinoma (PDAC) development is currently unclear. We therefore examined the consequences of disrupting paracrine Hedgehog (HH) signaling in PDAC stroma. Herein,...
7.
Peterson J, Wang D, Shettigar V, Roof S, Canan B, Bakkar N, et al.
Nat Commun
. 2018 Aug;
9(1):3431.
PMID: 30143619
Duchenne muscular dystrophy (DMD) is a neuromuscular disorder causing progressive muscle degeneration. Although cardiomyopathy is a leading mortality cause in DMD patients, the mechanisms underlying heart failure are not well...
8.
Ratnam N, Peterson J, Talbert E, Ladner K, Rajasekera P, Schmidt C, et al.
J Clin Invest
. 2017 Sep;
127(10):3796-3809.
PMID: 28891811
Macrophages are attracted to developing tumors and can participate in immune surveillance to eliminate neoplastic cells. In response, neoplastic cells utilize NF-κB to suppress this killing activity, but the mechanisms...
9.
Qian Z, Rhodes C, McCroskey L, Wen J, Appiah-Kubi G, Wang D, et al.
Angew Chem Int Ed Engl
. 2016 Dec;
56(6):1525-1529.
PMID: 28035784
Therapeutic applications of peptides are currently limited by their proteolytic instability and impermeability to the cell membrane. A general, reversible bicyclization strategy is now reported to increase both the proteolytic...
10.
Wang D, Lownie S, Pelz D, Pandey S
Interv Neuroradiol
. 2016 Jun;
22(5):596-9.
PMID: 27298012
Spinal synovial cysts are benign protrusions of facet joint capsules caused by degenerative spondylosis, most frequently involving the L4-5 level, and commonly lead to symptoms of back pain, radiculopathy and...