Benjamin R Pryce
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Explore the profile of Benjamin R Pryce including associated specialties, affiliations and a list of published articles.
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11
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55
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Recent Articles
1.
Pryce B, Oles A, Talbert E, Romeo M, Vaena S, Sharma S, et al.
Cell Rep
. 2024 Oct;
43(11):114925.
PMID: 39475511
Although cancer cachexia is classically characterized as a systemic inflammatory disorder, emerging evidence indicates that weight loss also associates with local tissue inflammation. We queried the regulation of this inflammation...
2.
Spadafora V, Pryce B, Oles A, Talbert E, Romeo M, Vaena S, et al.
BMC Cancer
. 2024 Apr;
24(1):414.
PMID: 38570770
Background: Pancreatic ductal adenocarcinoma (PDAC) presents with a high mortality rate. Two important features of PDAC contribute to this poor outcome. The first is metastasis which occurs in ~ 80%...
3.
Pryce B, Wang D, Zimmers T, Ostrowski M, Guttridge D
Cancer Cell
. 2023 Mar;
41(3):581-584.
PMID: 36868225
Advanced cancers often present with the cachexia syndrome that impacts peripheral tissues, leading to involuntary weight loss and reduced prognosis. The central tissues undergoing depletion are skeletal muscle and adipose,...
4.
Labreche C, Cook D, Abou-Hamad J, Pascoal J, Pryce B, Al-Zahrani K, et al.
Breast Cancer Res
. 2021 Nov;
23(1):107.
PMID: 34809697
Background: Breast cancer is a highly heterogeneous disease with multiple drivers and complex regulatory networks. Periostin (Postn) is a matricellular protein involved in a plethora of cancer types and other...
5.
Garland B, Delisle S, Al-Zahrani K, Pryce B, Sabourin L
J Cell Sci
. 2021 May;
134(9).
PMID: 33961052
Over the past 20 years, the Ste20-like kinase (SLK; also known as STK2) has emerged as a central regulator of cytoskeletal dynamics. Reorganization of the cytoskeleton is necessary for a...
6.
Pryce B, Labreche C, Hamoudi D, Abou-Hamad J, Al-Zahrani K, Hodgins J, et al.
Biochim Biophys Acta Mol Cell Res
. 2020 Dec;
1868(2):118917.
PMID: 33259860
Duchenne's muscular dystrophy (DMD) is a severe muscle wasting disorder characterized by the loss of dystrophin expression, muscle necrosis, inflammation and fibrosis. Ongoing muscle regeneration is impaired by persistent cytokine...
7.
Al-Zahrani K, Abou-Hamad J, Cook D, Pryce B, Hodgins J, Labreche C, et al.
Oncogene
. 2020 May;
39(23):4592-4602.
PMID: 32393835
HER2 is overexpressed in 20-30% of all breast cancers and is associated with an invasive disease and poor clinical outcome. The Ste20-like kinase (SLK) is activated downstream of HER2/Neu and...
8.
Ahmed S, Pryce B, Al-Zahrani K, Sabourin L
Biochim Biophys Acta Mol Cell Res
. 2018 Oct;
1865(11 Pt A):1590-1597.
PMID: 30327200
We have previously shown that the Ste20-like kinase SLK interacts directly with the LIM domain-binding protein 1, Ldb1. Ldb1 knock down in murine fibroblasts activates SLK and enhances cell migration....
9.
Conway J, Al-Zahrani K, Pryce B, Abou-Hamad J, Sabourin L
Oncotarget
. 2017 Dec;
8(58):98745-98756.
PMID: 29228724
Invasion can be stimulated using the soluble ligand transforming growth factor-β (TGFβ) to induce a process called epithelial-to-mesenchymal transition (EMT) characterized by cell-cell junction breakdown and an invasive phenotype. We...
10.
Pryce B, Al-Zahrani K, Dufresne S, Belkina N, Labreche C, Patino-Lopez G, et al.
Skelet Muscle
. 2017 Feb;
7(1):3.
PMID: 28153048
Background: The Ste20-like kinase, SLK, plays an important role in cell proliferation and cytoskeletal remodeling. In fibroblasts, SLK has been shown to respond to FAK/Src signaling and regulate focal adhesion...