David H MacLennan
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Explore the profile of David H MacLennan including associated specialties, affiliations and a list of published articles.
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57
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2632
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Recent Articles
21.
Gramolini A, Kislinger T, Alikhani-Koopaei R, Fong V, Thompson N, Isserlin R, et al.
Mol Cell Proteomics
. 2007 Dec;
7(3):519-33.
PMID: 18056057
Defective mobilization of Ca2+ by cardiomyocytes can lead to cardiac insufficiency, but the causative mechanisms leading to congestive heart failure (HF) remain unclear. In the present study we performed exhaustive...
22.
Morita T, Hussain D, Asahi M, Tsuda T, Kurzydlowski K, Toyoshima C, et al.
Biochem Biophys Res Commun
. 2007 Dec;
369(1):188-94.
PMID: 18053795
A robust cross-link between Gln(23) in phospholamban (PLN) and Lys(328) in the sarco(endo)plasmic reticulum Ca(2+) ATPase (SERCA1a) is formed in the presence or absence of oxidant and is susceptible to...
23.
Zvaritch E, Depreux F, Kraeva N, Loy R, Goonasekera S, Boncompagni S, et al.
Proc Natl Acad Sci U S A
. 2007 Nov;
104(47):18537-42.
PMID: 18003898
A heterozygous Ile4898 to Thr (I4898T) mutation in the human type 1 ryanodine receptor/Ca(2+) release channel (RyR1) leads to a severe form of central core disease. We created a mouse...
24.
Gramolini A, Kislinger T, Liu P, MacLennan D, Emili A
Methods Mol Biol
. 2006 Dec;
357:15-31.
PMID: 17172675
Cardiomyopathies are diseases of the heart resulting in impaired cardiac muscle function, which can lead to heart dilation or overt heart failure. These diseases represent a major cause of global...
25.
Arab S, Gramolini A, Ping P, Kislinger T, Stanley B, Van Eyk J, et al.
J Am Coll Cardiol
. 2006 Nov;
48(9):1733-41.
PMID: 17084242
Proteomics is the new systems biological approach to the study of proteins and protein variation on a large scale as a result of biological processes and perturbations. The field is...
26.
Trivieri M, Oudit G, Sah R, Kerfant B, Sun H, Gramolini A, et al.
Proc Natl Acad Sci U S A
. 2006 Apr;
103(15):6043-8.
PMID: 16595628
Thyroid hormone (TH) is critical for cardiac development and heart function. In heart disease, TH metabolism is abnormal, and many biochemical and functional alterations mirror hypothyroidism. Although TH therapy has...
27.
Gramolini A, Trivieri M, Oudit G, Kislinger T, Li W, Patel M, et al.
Proc Natl Acad Sci U S A
. 2006 Feb;
103(7):2446-51.
PMID: 16461894
Sarcolipin (SLN) inhibits the cardiac sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) by direct binding and is superinhibitory if it binds as a binary complex with phospholamban (PLN). To demonstrate whether overexpression...
28.
Haghighi K, Kolokathis F, Gramolini A, Waggoner J, Pater L, Lynch R, et al.
Proc Natl Acad Sci U S A
. 2006 Jan;
103(5):1388-93.
PMID: 16432188
The sarcoplasmic reticulum Ca(2+)-cycling proteins are key regulators of cardiac contractility, and alterations in sarcoplasmic reticulum Ca(2+)-cycling properties have been shown to be causal of familial cardiomyopathies. Through genetic screening...
29.
Monnier N, Kozak-Ribbens G, Krivosic-Horber R, Nivoche Y, Qi D, Kraev N, et al.
Hum Mutat
. 2005 Sep;
26(5):413-25.
PMID: 16163667
Malignant hyperthermia susceptibility (MHS) is a subclinical pharmacogenetic disorder caused by an impairment of skeletal muscle calcium homeostasis in response to triggering agents. While in vitro contracture testing (IVCT) is...
30.