David H MacLennan
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Explore the profile of David H MacLennan including associated specialties, affiliations and a list of published articles.
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57
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2632
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Recent Articles
11.
Kraeva N, Riazi S, Loke J, Frodis W, Crossan M, Nolan K, et al.
Can J Anaesth
. 2011 Apr;
58(6):504-13.
PMID: 21455645
Purpose: Malignant hyperthermia (MH) is an autosomal dominant pharmacogenetic disorder that is manifested on exposure of susceptible individuals to halogenated anesthetics or succinylcholine. Since MH is associated primarily with mutations...
12.
Ryan T, Sharma P, Ignatchenko A, MacLennan D, Kislinger T, Gramolini A
J Biol Chem
. 2011 Apr;
286(19):17060-8.
PMID: 21454501
The ryanodine receptor type 1 (RyR1) is a homotetrameric Ca(2+) release channel located in the sarcoplasmic reticulum of skeletal muscle where it plays a role in the initiation of skeletal...
13.
Loy R, Orynbayev M, Xu L, Andronache Z, Apostol S, Zvaritch E, et al.
J Gen Physiol
. 2010 Dec;
137(1):43-57.
PMID: 21149547
The type 1 isoform of the ryanodine receptor (RYR1) is the Ca(2+) release channel of the sarcoplasmic reticulum (SR) that is activated during skeletal muscle excitation-contraction (EC) coupling. Mutations in...
14.
MacLennan D, Zvaritch E
Biochim Biophys Acta
. 2010 Dec;
1813(5):948-64.
PMID: 21118704
This review focuses on muscle disorders and diseases caused by defects in the Ca(2+) release channels of the sarcoplasmic reticulum, the ryanodine receptors, and in the luminal, low affinity, high...
15.
Bousette N, Chugh S, Fong V, Isserlin R, Kim K, Volchuk A, et al.
Proc Natl Acad Sci U S A
. 2010 Oct;
107(43):18481-6.
PMID: 20937869
Cardiac-specific overexpression of a constitutively active form of calcineurin A (CNA) leads directly to cardiac hypertrophy in the CNA mouse model. Because cardiac hypertrophy is a prominent characteristic of many...
16.
Zvaritch E, Kraeva N, Bombardier E, McCloy R, Depreux F, Holmyard D, et al.
Proc Natl Acad Sci U S A
. 2009 Dec;
106(51):21813-8.
PMID: 19959667
Ryr1(I4895T/wt) (IT/+) mice express a knockin mutation corresponding to the human I4898T EC-uncoupling mutation in the type 1 ryanodine receptor/Ca(2+) release channel (RyR1), which causes a severe form of central...
17.
18.
Amador F, Liu S, Ishiyama N, Plevin M, Wilson A, MacLennan D, et al.
Proc Natl Acad Sci U S A
. 2009 Jun;
106(27):11040-4.
PMID: 19541610
Muscle contraction and relaxation is regulated by transient elevations of myoplasmic Ca(2+). Ca(2+) is released from stores in the lumen of the sarco(endo)plasmic reticulum (SER) to initiate formation of the...
19.
Schmitt J, Ahmad F, Lorenz K, Hein L, Schulz S, Asahi M, et al.
Circulation
. 2009 Jan;
119(3):436-44.
PMID: 19139388
Background: Low activity of the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA2a) resulting from strong inhibition by phospholamban (PLN) can depress cardiac contractility and lead to dilated cardiomyopathy and heart failure. Here, we...
20.
Zhu Y, Gramolini A, Walsh M, Zhou Y, Slorach C, Friedberg M, et al.
Proc Natl Acad Sci U S A
. 2008 Apr;
105(14):5519-24.
PMID: 18378906
At the end of every heartbeat, cardiac myocytes must relax to allow filling of the heart. Impaired relaxation is a significant factor in heart failure, but all pathways regulating the...