Peter H Backx
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Explore the profile of Peter H Backx including associated specialties, affiliations and a list of published articles.
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163
Citations
7913
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Recent Articles
1.
Huang K, Ashraf M, Rohani L, Luo Y, Sacayanan A, Huang H, et al.
Circ Genom Precis Med
. 2025 Jan;
18(1):e004412.
PMID: 39851047
Background: Protein-truncating mutations in the titin gene are associated with increased risk of atrial fibrillation. However, little is known about the underlying pathophysiology. Methods: We identified a heterozygous titin truncating...
2.
Hughes M, Ramos S, Brahmbhatt A, Turnbull P, Polidovitch N, Garibotti M, et al.
Redox Biol
. 2024 Aug;
76:103319.
PMID: 39178732
Mitochondrial creatine kinase (mtCK) regulates the "fast" export of phosphocreatine to support cytoplasmic phosphorylation of ADP to ATP which is more rapid than direct ATP export. Such "creatine-dependent" phosphate shuttling...
3.
Hamidzada H, Pascual-Gil S, Wu Q, Kent G, Masse S, Kantores C, et al.
Nat Cardiovasc Res
. 2024 Aug;
3(5):567-593.
PMID: 39086373
Yolk sac macrophages are the first to seed the developing heart, however we have no understanding of their roles in human heart development and function due to a lack of...
4.
Gorman R, Yakobov S, Polidovitch N, Debi R, Sanfrancesco V, Hood D, et al.
J Physiol
. 2024 Feb;
602(4):569-596.
PMID: 38319954
Atrial fibrillation (AF) is a supraventricular tachyarrhythmia that is strongly associated with cardiovascular (CV) disease and sedentary lifestyles. Despite the benefits of exercise on overall health, AF incidence in high-level...
5.
Li X, You J, Dai F, Wang S, Yang F, Wang X, et al.
JACC Basic Transl Sci
. 2024 Jan;
8(12):1555-1573.
PMID: 38205342
A comprehensive view of the role of NLRP3/caspase-1/GSDMD-mediated pyroptosis in pressure overload cardiac hypertrophy is presented in this study. Furthermore, mitigation of NLRP3 deficiency-induced pyroptosis confers cardioprotection against pressure overload...
6.
Zheng S, Tan W, Li X, Wang L, Zhu C, Pyle W, et al.
Front Pharmacol
. 2023 Nov;
14:1145413.
PMID: 37942483
While the protective effects of n-3 polyunsaturated fatty acids (PUFAs) on cardiac ischemia-reperfusion (IR) injury have been previously reported, limited data are available regarding how these fatty acids affect membrane...
7.
Lakin R, Polidovitch N, Yang S, Parikh M, Liu X, Debi R, et al.
Cardiovasc Res
. 2023 Sep;
119(16):2607-2622.
PMID: 37713664
Aims: Endurance exercise is associated with an increased risk of atrial fibrillation (AF). We previously established that adverse atrial remodelling and AF susceptibility induced by intense exercise in mice require...
8.
Wauchop M, Rafatian N, Zhao Y, Chen W, Gagliardi M, Masse S, et al.
Biomaterials
. 2023 Aug;
301:122255.
PMID: 37651922
To better understand sodium channel (SCN5A)-related cardiomyopathies, we generated ventricular cardiomyocytes from induced pluripotent stem cells obtained from a dilated cardiomyopathy patient harbouring the R222Q mutation, which is only expressed...
9.
Reitz C, Tavassoli M, Kim D, Shah S, Lakin R, Teng A, et al.
Proc Natl Acad Sci U S A
. 2023 May;
120(19):e2212118120.
PMID: 37126683
The prognosis and treatment outcomes of heart failure (HF) patients rely heavily on disease etiology, yet the majority of underlying signaling mechanisms are complex and not fully elucidated. Phosphorylation is...
10.
Teng A, Gu L, Di Paola M, Lakin R, Williams Z, Au A, et al.
Nat Commun
. 2022 Oct;
13(1):6166.
PMID: 36257954
The intercalated disc (ICD) is a unique membrane structure that is indispensable to normal heart function, yet its structural organization is not completely understood. Previously, we showed that the ICD-bound...