David Ginsburg
Overview
Explore the profile of David Ginsburg including associated specialties, affiliations and a list of published articles.
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Articles
118
Citations
3558
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Recent Articles
1.
Ward M, Holding M, Haynes L, Ginsburg D
bioRxiv
. 2025 Jan;
PMID: 39829938
Tandem duplication of genes can play a critical role in the evolution of functional novelty, but our understanding is limited concerning gene duplication's role in coevolution between species. Much is...
2.
3.
Haynes L, Holding M, DiGiovanni H, Siemieniak D, Ginsburg D
bioRxiv
. 2024 Sep;
PMID: 39345533
While members of large paralogous protein families share structural features, their functional niches often diverge significantly. Serine protease inhibitors (SERPINs), whose members typically function as covalent inhibitors of serine proteases,...
4.
Tang V, Xiang J, Chen Z, McCormick J, Abbineni P, Chen X, et al.
Proc Natl Acad Sci U S A
. 2024 Apr;
121(19):e2322164121.
PMID: 38687799
Proteins carrying a signal peptide and/or a transmembrane domain enter the intracellular secretory pathway at the endoplasmic reticulum (ER) and are transported to the Golgi apparatus via COPII vesicles or...
5.
Tang V, Xiang J, Chen Z, McCormick J, Abbineni P, Chen X, et al.
bioRxiv
. 2024 Mar;
PMID: 38463989
Proteins carrying a signal peptide and/or a transmembrane domain enter the intracellular secretory pathway at the endoplasmic reticulum (ER) and are transported to the Golgi apparatus via COPII vesicles or...
6.
Tang V, Abbineni P, Veiga Leprevost F, Basrur V, Khoriaty R, Emmer B, et al.
J Proteome Res
. 2023 Oct;
22(11):3439-3446.
PMID: 37844105
Most proteins secreted into the extracellular space are first recruited from the endoplasmic reticulum into coat protein complex II (COPII)-coated vesicles or tubules that facilitate their transport to the Golgi...
7.
Thompson A, Wagner M, Rodriguez J, Malhotra A, Vander Roest S, Lilienthal U, et al.
JACC Basic Transl Sci
. 2023 Oct;
8(9):1198-1211.
PMID: 37791314
Variants in the gene myosin-binding protein C3 () account for approximately 50% of familial hypertrophic cardiomyopathy (HCM), leading to reduced levels of myosin-binding protein C3 (MyBP-C), the protein product made...
8.
Tang V, Abbineni P, Veiga Leprevost F, Basrur V, Emmer B, Nesvizhskii A, et al.
bioRxiv
. 2023 Apr;
PMID: 37066360
Most proteins secreted into the extracellular space are first recruited from the endoplasmic reticulum into coat protein complex II (COPII)-coated vesicles or tubules that facilitate their transport to the Golgi...
9.
Tang V, Ginsburg D
J Clin Invest
. 2023 Jan;
133(1).
PMID: 36594468
Most proteins destined for the extracellular space or various intracellular compartments must traverse the intracellular secretory pathway. The first step is the recruitment and transport of cargoes from the endoplasmic...
10.
Haynes L, Huttinger Z, Yee A, Kretz C, Siemieniak D, Lawrence D, et al.
J Biol Chem
. 2022 Oct;
298(12):102608.
PMID: 36257408
Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor superfamily of proteins, is unique among serine protease inhibitors for exhibiting a spontaneous conformational change to a latent or...