David Ginsburg
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Explore the profile of David Ginsburg including associated specialties, affiliations and a list of published articles.
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118
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3558
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Recent Articles
11.
Tang V, McCormick J, Xu B, Wang Y, Fang H, Wang X, et al.
Elife
. 2022 Oct;
11.
PMID: 36193893
PCSK9 negatively regulates low-density lipoprotein receptor (LDLR) abundance on the cell surface, leading to decreased hepatic clearance of LDL particles and increased levels of plasma cholesterol. We previously identified SURF4...
12.
Abbineni P, Tang V, Veiga Leprevost F, Basrur V, Xiang J, Nesvizhskii A, et al.
Anal Biochem
. 2022 Aug;
655:114846.
PMID: 35973625
Analysis of the full spectrum of secreted proteins in cell culture is complicated by leakage of intracellular proteins from damaged cells. To address this issue, we compared the abundance of...
13.
Khan T, Ginsburg D, Emmer B
J Lipid Res
. 2022 Jun;
63(8):100248.
PMID: 35753407
The low-density lipoprotein receptor (LDLR) mediates the hepatic uptake of circulating low-density lipoproteins (LDLs), a process that modulates the development of atherosclerotic cardiovascular disease. We recently identified RAB10, encoding a...
14.
Yu L, Myers G, Schneider E, Wang Y, Mathews R, Lim K, et al.
Blood Adv
. 2022 Mar;
6(11):3280-3285.
PMID: 35240686
Human γ-globin is predominantly expressed in fetal liver erythroid cells during gestation from 2 nearly identical genes, HBG1 and HBG2, that are both perinatally silenced. Reactivation of these fetal genes...
15.
Adams E, Khoriaty R, Kiseleva A, Cleuren A, Tomberg K, van der Ent M, et al.
Sci Rep
. 2021 Oct;
11(1):21100.
PMID: 34702932
The COPII component SEC24 mediates the recruitment of transmembrane cargos or cargo adaptors into newly forming COPII vesicles on the ER membrane. Mammalian genomes encode four Sec24 paralogs (Sec24a-d), with...
16.
Huttinger Z, Haynes L, Yee A, Kretz C, Holding M, Siemieniak D, et al.
Sci Rep
. 2021 Sep;
11(1):18827.
PMID: 34552126
The serine protease inhibitor (SERPIN) plasminogen activator inhibitor-1 (PAI-1) is a key regulator of the fibrinolytic system, inhibiting the serine proteases tissue- and urokinase-type plasminogen activator (tPA and uPA, respectively)....
17.
Yee A, Dai M, Croteau S, Shavit J, Pipe S, Siemieniak D, et al.
J Thromb Haemost
. 2021 Jul;
19(11):2702-2709.
PMID: 34255925
Background: Correction of von Willebrand factor (VWF) deficiency with replacement products containing VWF can lead to the development of anti-VWF alloantibodies (i.e., VWF inhibitors) in patients with severe von Willebrand...
18.
de Mattos Barbosa M, Liu H, Huynh D, Shelley G, Keller E, Emmer B, et al.
JCI Insight
. 2021 Mar;
6(9).
PMID: 33769311
Abs that neutralize SARS-CoV-2 are thought to provide the most immediate and effective treatment for those severely afflicted by this virus. Because coronavirus potentially diversifies by mutation, broadly neutralizing Abs...
19.
Emmer B, Sherman E, Lascuna P, Graham S, Willer C, Ginsburg D
PLoS Genet
. 2021 Jan;
17(1):e1009285.
PMID: 33513160
Hypercholesterolemia is a causal and modifiable risk factor for atherosclerotic cardiovascular disease. A critical pathway regulating cholesterol homeostasis involves the receptor-mediated endocytosis of low-density lipoproteins into hepatocytes, mediated by the...
20.
Kim S, Khoriaty R, Li L, McClune M, Kalfa T, Wu J, et al.
J Clin Invest
. 2021 Jan;
131(2).
PMID: 33463537
T cell-mediated responses are dependent on their secretion of key effector molecules. However, the critical molecular determinants of the secretion of these proteins are largely undefined. Here, we demonstrate that...