David Siemieniak
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Explore the profile of David Siemieniak including associated specialties, affiliations and a list of published articles.
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11
Citations
181
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Recent Articles
1.
Haynes L, Holding M, DiGiovanni H, Siemieniak D, Ginsburg D
bioRxiv
. 2024 Sep;
PMID: 39345533
While members of large paralogous protein families share structural features, their functional niches often diverge significantly. Serine protease inhibitors (SERPINs), whose members typically function as covalent inhibitors of serine proteases,...
2.
Tang V, McCormick J, Xu B, Wang Y, Fang H, Wang X, et al.
Elife
. 2022 Oct;
11.
PMID: 36193893
PCSK9 negatively regulates low-density lipoprotein receptor (LDLR) abundance on the cell surface, leading to decreased hepatic clearance of LDL particles and increased levels of plasma cholesterol. We previously identified SURF4...
3.
Yu L, Myers G, Schneider E, Wang Y, Mathews R, Lim K, et al.
Blood Adv
. 2022 Mar;
6(11):3280-3285.
PMID: 35240686
Human γ-globin is predominantly expressed in fetal liver erythroid cells during gestation from 2 nearly identical genes, HBG1 and HBG2, that are both perinatally silenced. Reactivation of these fetal genes...
4.
Yee A, Dai M, Croteau S, Shavit J, Pipe S, Siemieniak D, et al.
J Thromb Haemost
. 2021 Jul;
19(11):2702-2709.
PMID: 34255925
Background: Correction of von Willebrand factor (VWF) deficiency with replacement products containing VWF can lead to the development of anti-VWF alloantibodies (i.e., VWF inhibitors) in patients with severe von Willebrand...
5.
Lin Z, King R, Tang V, Myers G, Balbin-Cuesta G, Friedman A, et al.
Mol Cell Biol
. 2020 Sep;
40(23).
PMID: 32989016
Erythropoietin (EPO) stimulates erythroid differentiation and maturation. Though the transcriptional regulation of EPO has been well studied, the molecular determinants of EPO secretion remain unknown. Here, we generated a HEK293T...
6.
Khoriaty R, Ozel A, Ramdas S, Ross C, Desch K, Shavit J, et al.
Br J Haematol
. 2019 May;
186(4):574-579.
PMID: 31119735
Hereditary thrombocytopenias can be subclassified based on mode of inheritance and platelet size. Here we report a family with autosomal dominant (AD) thrombocytopenia with normal platelet size. Linkage analysis and...
7.
Kretz C, Dai M, Soylemez O, Yee A, Desch K, Siemieniak D, et al.
Proc Natl Acad Sci U S A
. 2015 Jul;
112(30):9328-33.
PMID: 26170332
Proteases play important roles in many biologic processes and are key mediators of cancer, inflammation, and thrombosis. However, comprehensive and quantitative techniques to define the substrate specificity profile of proteases...
8.
Ma Q, Ozel A, Ramdas S, McGee B, Khoriaty R, Siemieniak D, et al.
Blood
. 2014 Sep;
124(20):3155-64.
PMID: 25208887
Plasminogen is the precursor of the serine protease plasmin, a central enzyme of the fibrinolytic system. Plasma levels of plasminogen vary by almost 2-fold among healthy individuals, yet little is...
9.
Khoriaty R, Vasievich M, Jones M, Everett L, Chase J, Tao J, et al.
Mol Cell Biol
. 2014 Jul;
34(19):3721-34.
PMID: 25071156
Congenital dyserythropoietic anemia type II (CDAII) is an autosomal recessive disease of ineffective erythropoiesis characterized by increased bi/multinucleated erythroid precursors in the bone marrow. CDAII results from mutations in SEC23B....
10.
Desch K, Ozel A, Siemieniak D, Kalish Y, Shavit J, Thornburg C, et al.
Proc Natl Acad Sci U S A
. 2012 Dec;
110(2):588-93.
PMID: 23267103
The plasma glycoprotein von Willebrand factor (VWF) exhibits fivefold antigen level variation across the normal human population determined by both genetic and environmental factors. Low levels of VWF are associated...