David D Shock
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Explore the profile of David D Shock including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Jamsen J, Shock D, Wilson S
Nat Commun
. 2022 Jun;
13(1):3193.
PMID: 35680862
Efficient and accurate DNA synthesis is enabled by DNA polymerase fidelity checkpoints that promote insertion of the right instead of wrong nucleotide. Erroneous X-family polymerase (pol) λ nucleotide insertion leads...
2.
Jamsen J, Sassa A, Perera L, Shock D, Beard W, Wilson S
Nat Commun
. 2021 Aug;
12(1):5055.
PMID: 34417448
Reactive oxygen species (ROS) oxidize cellular nucleotide pools and cause double strand breaks (DSBs). Non-homologous end-joining (NHEJ) attaches broken chromosomal ends together in mammalian cells. Ribonucleotide insertion by DNA polymerase...
3.
Jamsen J, Sassa A, Shock D, Beard W, Wilson S
Nat Commun
. 2021 Apr;
12(1):2059.
PMID: 33824325
Oxidized dGTP (8-oxo-7,8-dihydro-2´-deoxyguanosine triphosphate, 8-oxodGTP) insertion by DNA polymerases strongly promotes cancer and human disease. How DNA polymerases discriminate against oxidized and undamaged nucleotides, especially in error-prone double strand break...
4.
Perera L, Beard W, Pedersen L, Shock D, Wilson S
ACS Omega
. 2020 Jul;
5(25):15317-15324.
PMID: 32637805
DNA replication and repair reactions involve the addition of a deoxynucleoside monophosphate onto a growing DNA strand with the loss of pyrophosphate. This chemical reaction is also reversible; the addition...
5.
Howard M, Cavanaugh N, Batra V, Shock D, Beard W, Wilson S
J Biol Chem
. 2019 Dec;
295(2):529-538.
PMID: 31801827
DNA polymerase β has two DNA-binding domains that interact with the opposite sides of short DNA gaps. These domains contribute two activities that modify the 5' and 3' margins of...
6.
Howard M, Foley K, Shock D, Batra V, Wilson S
J Biol Chem
. 2019 Mar;
294(18):7194-7201.
PMID: 30885943
DNA methylation is an epigenetic mark that regulates gene expression in mammals. One method of methylation removal is through ten-eleven translocation-catalyzed oxidation and the base excision repair pathway. The iterative...
7.
Smith M, Shock D, Beard W, Greenberg M, Freudenthal B, Wilson S
Nucleic Acids Res
. 2019 Jan;
47(6):3197-3207.
PMID: 30649431
4,6-Diamino-5-formamidopyrimidine (Fapy•dG) is an abundant form of oxidative DNA damage that is mutagenic and contributes to the pathogenesis of human disease. When Fapy•dG is in its nucleotide triphosphate form, Fapy•dGTP,...
8.
Jamsen J, Beard W, Pedersen L, Shock D, Moon A, Krahn J, et al.
Nat Commun
. 2017 Aug;
8(1):253.
PMID: 28811466
DNA polymerase (pol) μ is a DNA-dependent polymerase that incorporates nucleotides during gap-filling synthesis in the non-homologous end-joining pathway of double-strand break repair. Here we report time-lapse X-ray crystallography snapshots...
9.
Shock D, Freudenthal B, Beard W, Wilson S
Nat Chem Biol
. 2017 Aug;
13(10):1074-1080.
PMID: 28759020
DNA polymerases catalyze efficient and high-fidelity DNA synthesis. While this reaction favors nucleotide incorporation, polymerases also catalyze a reverse reaction, pyrophosphorolysis, that removes the DNA primer terminus and generates deoxynucleoside...
10.
Perera L, Freudenthal B, Beard W, Shock D, Pedersen L, Wilson S
Proc Natl Acad Sci U S A
. 2015 Sep;
112(38):E5228-36.
PMID: 26351676
DNA polymerases facilitate faithful insertion of nucleotides, a central reaction occurring during DNA replication and repair. DNA synthesis (forward reaction) is "balanced," as dictated by the chemical equilibrium by the...