Charles E McKenna
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Explore the profile of Charles E McKenna including associated specialties, affiliations and a list of published articles.
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121
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1820
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Recent Articles
1.
Wei K, Arlotto M, Overhulse J, Dinh T, Zhou Y, Dupper N, et al.
Adv Sci (Weinh)
. 2025 Jan;
12(10):e2404260.
PMID: 39821709
The fungal Bromodomain and Extra-Terminal (BET) protein Bdf1 is a potential antifungal target against invasive fungal infections. However, the need to selectively inhibit both Bdf1 bromodomains (BDs) over human orthologs...
2.
Yang J, Riemann S, Lyu J, Feng S, Bi Y, Lentini N, et al.
bioRxiv
. 2024 Nov;
PMID: 39554161
Adenovirus infections of immunocompromised humans are a significant source of morbidity and mortality. At present, no drug has been approved by FDA for the treatment of adenovirus infections. A current...
3.
Alnajjar K, Wang K, Alvarado-Cruz I, Chavira C, Negahbani A, Nakhjiri M, et al.
Biochemistry
. 2024 May;
63(11):1412-1422.
PMID: 38780930
The catalytic function of DNA polymerase β (pol β) fulfills the gap-filling requirement of the base excision DNA repair pathway by incorporating a single nucleotide into a gapped DNA substrate...
4.
Shi B, Sriram V, Wu S, Huang D, Cheney A, Metzger M, et al.
Front Bioeng Biotechnol
. 2024 Mar;
12:1308161.
PMID: 38433822
Osteoadsorptive fluorogenic sentinel 3 (OFS-3) is a recently described compound that contains a bone-targeting bisphosphonate (BP) and cathepsin K (Ctsk)-triggered fluorescence signal. A prior study in a murine Achilles repair...
5.
Seebald L, Haratipour P, Jacobs M, Bernstein H, Kashemirov B, McKenna C, et al.
J Am Chem Soc
. 2024 Jan;
146(5):3220-3229.
PMID: 38271668
Complex bacterial glycoconjugates drive interactions between pathogens, symbionts, and their human hosts. Glycoconjugate biosynthesis is initiated at the membrane interface by phosphoglycosyl transferases (PGTs), which catalyze the transfer of a...
6.
Tollefson A, Riemann S, Ying B, Spencer J, Overhulse J, Kashemirov B, et al.
Antiviral Res
. 2024 Jan;
222:105799.
PMID: 38190973
Adenovirus infections of immunocompromised humans are a significant source of morbidity and mortality. Presently, there is no drug specifically approved for the treatment of adenovirus infections by the FDA. The...
7.
Ren Y, Weeks J, Xue T, Rainbolt J, Bentley K, Shu Y, et al.
Bone Res
. 2023 Oct;
11(1):51.
PMID: 37848449
Eradication of MRSA osteomyelitis requires elimination of distinct biofilms. To overcome this, we developed bisphosphonate-conjugated sitafloxacin (BCS, BV600072) and hydroxybisphosphonate-conjugate sitafloxacin (HBCS, BV63072), which achieve "target-and-release" drug delivery proximal to...
8.
Seebald L, Haratipour P, Jacobs M, Bernstein H, Kashemirov B, McKenna C, et al.
bioRxiv
. 2023 Oct;
PMID: 37786673
Complex bacterial glycoconjugates are essential for bacterial survival, and drive interactions between pathogens and symbionts, and their human hosts. Glycoconjugate biosynthesis is initiated at the membrane interface by phosphoglycosyl transferases...
9.
Jacobs M, Olivero J, Ok Choi H, Liao C, Kashemirov B, Katz J, et al.
Bioorg Med Chem
. 2023 Aug;
92:117425.
PMID: 37544256
Monoamine oxidases (MAOA/MAOB) are enzymes known for their role in neurotransmitter regulation in the central nervous system (CNS). Irreversible and non-selective MAO inhibitors (MAOi's) were the first class of antidepressants,...
10.
Mustafa D, Overhulse J, Kashemirov B, McKenna C
Molecules
. 2023 Apr;
28(8).
PMID: 37110732
Phosphonic acids represent one of the most important categories of organophosphorus compounds, with myriad examples found in chemical biology, medicine, materials, and other domains. Phosphonic acids are rapidly and conveniently...