Paul R Fleming
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Explore the profile of Paul R Fleming including associated specialties, affiliations and a list of published articles.
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10
Citations
125
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Recent Articles
1.
Fleming P, Forrester S, McLaren N
Proc Inst Mech Eng P J Sport Eng Technol
. 2018 May;
229(3):169-182.
PMID: 29708108
Third generation artificial grass pitches have been observed to get harder over time. The maintenance technique of rubber infill decompaction is intended to help slow, or reverse, this process. At...
2.
Rose J, Lahiri S, McKinney D, Albert R, Morningstar M, Shapiro A, et al.
Bioorg Med Chem Lett
. 2015 Jun;
25(16):3301-6.
PMID: 26099541
With increasing emergence of multi-drug resistant infections, there is a dire need for new classes of compounds that act through unique mechanisms. In this work, we describe the discovery and...
3.
Molodtsov V, Fleming P, Eyermann C, Ferguson A, Foulk M, McKinney D, et al.
J Med Chem
. 2015 Mar;
58(7):3156-71.
PMID: 25798859
Squaramides constitute a novel class of RNA polymerase inhibitors of which genetic evidence and computational modeling previously have suggested an inhibitory mechanism mediated by binding to the RNA polymerase switch...
4.
McLeod S, Fleming P, MacCormack K, McLaughlin R, Whiteaker J, Narita S, et al.
J Bacteriol
. 2015 Jan;
197(6):1075-82.
PMID: 25583975
In Gram-negative bacteria, lipoproteins are transported to the outer membrane by the Lol system. In this process, lipoproteins are released from the inner membrane by the ABC transporter LolCDE and...
5.
Hopper L, Wheeler T, Webster J, Allen N, Roberts J, Fleming P
J Dance Med Sci
. 2014 Dec;
18(3):121-30.
PMID: 25474177
The mechanical properties of dance floors have the potential to influence dancers' performance and injury risk. Little information is available that describes dancers' preferences for dance floor mechanical properties. Investigation...
6.
Fan J, de Jonge B, MacCormack K, Sriram S, McLaughlin R, Plant H, et al.
Antimicrob Agents Chemother
. 2014 Sep;
58(12):7264-72.
PMID: 25246396
Bacterial biosensor strains can be useful tools for the discovery and characterization of antibacterial compounds. A plasmid-based reporter vector containing a transcriptional fusion between the recA promoter and green fluorescence...
7.
Abibi A, Ferguson A, Fleming P, Gao N, Hajec L, Hu J, et al.
J Biol Chem
. 2014 Jun;
289(31):21651-62.
PMID: 24936059
The antimicrobial activity of phenyl-thiazolylurea-sulfonamides against Staphylococcus aureus PheRS are dependent upon phenylalanine levels in the extracellular fluids. Inhibitor efficacy in animal models of infection is substantially diminished by dietary...
8.
Xiong H, Foulk M, Aschenbrenner L, Fan J, Tiong-Yip C, Johnson K, et al.
Bioorg Med Chem Lett
. 2013 Nov;
23(24):6789-93.
PMID: 24211022
Targeting viral polymerases has been a proven and attractive strategy for antiviral drug discovery. Herein we describe our effort in improving the antiviral activity and physical properties of a series...
9.
Buurman E, Foulk M, Gao N, Laganas V, McKinney D, Moustakas D, et al.
J Bacteriol
. 2012 Jul;
194(20):5504-12.
PMID: 22843845
A series of inhibitors with a squaramide core was synthesized following its discovery in a high-throughput screen for novel inhibitors of a transcription-coupled translation assay using Escherichia coli S30 extracts....
10.
Geng B, Fleming P, Umlauf S, Lin A, Pallai P
Bioorg Med Chem Lett
. 2002 Feb;
12(5):775-8.
PMID: 11859000
Novel phenol bis-Mannich adducts were identified as IL-2 expression inhibitors in a T cell proliferation screening assay. Analogues of the lead compound were prepared through parallel synthesis and a highly...