Darren R Heintzman
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Explore the profile of Darren R Heintzman including associated specialties, affiliations and a list of published articles.
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9
Citations
177
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Recent Articles
1.
Arner E, Jennings E, Crooks D, Ricketts C, Wolf M, Cottam M, et al.
bioRxiv
. 2025 Jan;
PMID: 39829901
Metastasis causes most cancer deaths and reflects transitions from primary tumor escape to seeding and growth at metastatic sites. Epithelial-to-mesenchymal transition (EMT) is important early in metastasis to enable cancer...
2.
Chowdhury N, Cephus J, Henriquez Pilier E, Wolf M, Madden M, Kuehnle S, et al.
J Clin Invest
. 2024 Oct;
134(23).
PMID: 39404231
Female individuals have an increased prevalence of many Th17 cell-mediated diseases, including asthma. Androgen signaling decreases Th17 cell-mediated airway inflammation, and Th17 cells rely on glutaminolysis. However, it remains unclear...
3.
Subset-specific mitochondrial stress and DNA damage shape T cell responses to fever and inflammation
Heintzman D, Sinard R, Fisher E, Ye X, Patterson A, Elasy J, et al.
Sci Immunol
. 2024 Sep;
9(99):eadp3475.
PMID: 39303018
Heat is a cardinal feature of inflammation, yet its impacts on immune cells remain uncertain. We show that moderate-grade fever temperatures (39°C) increased murine CD4 T cell metabolism, proliferation, and...
4.
Sugiura A, Beier K, Chi C, Heintzman D, Ye X, Wolf M, et al.
bioRxiv
. 2023 Sep;
PMID: 37745344
Amino acid (AA) uptake is essential for T cell metabolism and function, but how tissue sites and inflammation affect CD4 T cell subset requirements for specific AA remains uncertain. Here...
5.
Campos L, Van Ravenstein S, Vontalge E, Greer B, Heintzman D, Kavlashvili T, et al.
Cell Rep
. 2023 Feb;
42(2):112109.
PMID: 36807139
Topological stress can cause converging replication forks to stall during termination of vertebrate DNA synthesis. However, replication forks ultimately overcome fork stalling, suggesting that alternative mechanisms of termination exist. Using...
6.
Heintzman D, Fisher E, Rathmell J
Cell Mol Immunol
. 2022 Jan;
19(3):316-326.
PMID: 35039633
T cell metabolism is dynamic and highly regulated. While the intrinsic metabolic programs of T cell subsets are integral to their distinct differentiation and functional patterns, the ability of cells...
7.
Sugiura A, Andrejeva G, Voss K, Heintzman D, Xu X, Madden M, et al.
Immunity
. 2021 Nov;
55(1):65-81.e9.
PMID: 34767747
Antigenic stimulation promotes T cell metabolic reprogramming to meet increased biosynthetic, bioenergetic, and signaling demands. We show that the one-carbon (1C) metabolism enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) regulates de novo...
8.
Marinko J, Wright M, Schlebach J, Clowes K, Heintzman D, Plate L, et al.
J Biol Chem
. 2021 May;
296:100719.
PMID: 33933451
Peripheral myelin protein 22 (PMP22) folds and trafficks inefficiently, with only 20% of newly expressed protein trafficking to the cell surface. This behavior is exacerbated in many of the mutants...
9.
Mehta K, Lovejoy C, Zhao R, Heintzman D, Cortez D
Cell Rep
. 2020 Jun;
31(9):107705.
PMID: 32492421
5-Hydroxymethylcytosine (5hmC) binding, ES-cell-specific (HMCES) crosslinks to apurinic or apyrimidinic (AP, abasic) sites in single-strand DNA (ssDNA). To determine whether HMCES responds to the ssDNA abasic site in cells, we...
10.
Heintzman D, Campos L, Byl J, Osheroff N, Dewar J
Cell Rep
. 2019 Oct;
29(2):422-436.e5.
PMID: 31597101
Termination of DNA replication occurs when two replication forks converge upon the same stretch of DNA. Resolution of topological stress by topoisomerases is crucial for fork convergence in bacteria and...