Jeffrey C Rathmell
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Explore the profile of Jeffrey C Rathmell including associated specialties, affiliations and a list of published articles.
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209
Citations
18593
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Recent Articles
1.
Fu H, Vuononvirta J, Fanti S, Bonacina F, dAmati A, Wang G, et al.
Nat Metab
. 2025 Feb;
PMID: 40000839
No abstract available.
2.
Wilander B, Rathmell J
Trends Immunol
. 2025 Feb;
PMID: 39984354
Fevers are an ancient feature of the inflammatory microenvironment. While fevers may improve the immune response to pathogens, mechanisms are unclear. We explore recent studies of how fever-range temperatures inform...
3.
Stier M, Sewell A, Mwizerwa E, Sim C, Tanner S, Nichols C, et al.
bioRxiv
. 2025 Feb;
PMID: 39975258
Host immunity in sepsis has features of hyperinflammation together with progressive immunosuppression, particularly among CD4 T cells, that can predispose to secondary infections and ineffectual organ recovery. Metabolic and immunologic...
4.
Pierro E, Cottam M, An H, Lehmann B, Pietenpol J, Wellen K, et al.
Cancer Res
. 2025 Jan;
PMID: 39841585
Obesity is an established risk factor for breast cancer development and poor prognosis. The adipose environment surrounding breast tumors, which is inflamed in obesity, has been implicated in tumor progression,...
5.
Arner E, Jennings E, Crooks D, Ricketts C, Wolf M, Cottam M, et al.
bioRxiv
. 2025 Jan;
PMID: 39829901
Metastasis causes most cancer deaths and reflects transitions from primary tumor escape to seeding and growth at metastatic sites. Epithelial-to-mesenchymal transition (EMT) is important early in metastasis to enable cancer...
6.
Stone S, Rathmell J, Bader J
Cell Chem Biol
. 2024 Dec;
31(12):2021-2023.
PMID: 39706167
Obesity is a leading risk factor and a negative prognostic indicator for many cancers. In a recent issue of Science Immunology, Bagchi et al. identified that tumor-associated macrophages upregulate GPR65...
7.
Zhen X, Betti M, Kars M, Patterson A, Medina-Torres E, Scheffler Mendoza S, et al.
J Clin Immunol
. 2024 Dec;
45(1):53.
PMID: 39630167
G6PC3 deficiency is a monogenic immunometabolic disorder that causes severe congenital neutropenia type 4. Patients display heterogeneous extra-hematological manifestations, contributing to delayed diagnosis. Here, we investigated the origin and functional...
8.
Amancherla K, Schlendorf K, Chow N, Sheng Q, Freedman J, Rathmell J
J Heart Lung Transplant
. 2024 Nov;
PMID: 39580136
Background: Cardiac allograft vasculopathy (CAV) is the leading cause of late graft failure and mortality after heart transplantation (HT). Current strategies for early diagnosis and effective treatment of CAV are...
9.
Islam M, Yang Y, Simmons A, Shah V, Musale K, Xu Y, et al.
Nature
. 2024 Oct;
634(8036):1187-1195.
PMID: 39478207
Temporal ordering of cellular events offers fundamental insights into biological phenomena. Although this is traditionally achieved through continuous direct observations, an alternative solution leverages irreversible genetic changes, such as naturally...
10.
Chowdhury N, Cephus J, Henriquez Pilier E, Wolf M, Madden M, Kuehnle S, et al.
J Clin Invest
. 2024 Oct;
134(23).
PMID: 39404231
Female individuals have an increased prevalence of many Th17 cell-mediated diseases, including asthma. Androgen signaling decreases Th17 cell-mediated airway inflammation, and Th17 cells rely on glutaminolysis. However, it remains unclear...