Channing Chi
Overview
Explore the profile of Channing Chi including associated specialties, affiliations and a list of published articles.
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8
Citations
9
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Recent Articles
1.
Chowdhury N, Cephus J, Henriquez Pilier E, Wolf M, Madden M, Kuehnle S, et al.
J Clin Invest
. 2024 Oct;
134(23).
PMID: 39404231
Female individuals have an increased prevalence of many Th17 cell-mediated diseases, including asthma. Androgen signaling decreases Th17 cell-mediated airway inflammation, and Th17 cells rely on glutaminolysis. However, it remains unclear...
2.
Subset-specific mitochondrial stress and DNA damage shape T cell responses to fever and inflammation
Heintzman D, Sinard R, Fisher E, Ye X, Patterson A, Elasy J, et al.
Sci Immunol
. 2024 Sep;
9(99):eadp3475.
PMID: 39303018
Heat is a cardinal feature of inflammation, yet its impacts on immune cells remain uncertain. We show that moderate-grade fever temperatures (39°C) increased murine CD4 T cell metabolism, proliferation, and...
3.
Patterson A, Needle G, Sugiura A, Jennings E, Chi C, Steiner K, et al.
Sci Immunol
. 2024 Aug;
9(98):eadh0368.
PMID: 39151020
Inborn errors of metabolism (IEMs) and immunity (IEIs) are Mendelian diseases in which complex phenotypes and patient rarity have limited clinical understanding. Whereas few genes have been annotated as contributing...
4.
Steiner K, Young A, Patterson A, Jennings E, Chi C, Hatem Z, et al.
bioRxiv
. 2024 Jul;
PMID: 39026793
Lipid metabolism is fundamental to CD4+ T cell metabolism yet remains poorly understood across subsets. Therefore, we performed targeted in vivo CRISPR/Cas9 screens to identify lipid-associated genes essential for T...
5.
Voss K, Bartkowiak T, Sewell A, Chi C, Landis M, Schaefer S, et al.
Immunohorizons
. 2024 Jul;
8(7):492-499.
PMID: 39008056
The transcription factor FOXN1 plays an established role in thymic epithelial development to mediate selection of maturing thymocytes. Patients with heterozygous loss-of-function FOXN1 variants are associated with T cell lymphopenia...
6.
Sugiura A, Beier K, Chi C, Heintzman D, Ye X, Wolf M, et al.
bioRxiv
. 2023 Sep;
PMID: 37745344
Amino acid (AA) uptake is essential for T cell metabolism and function, but how tissue sites and inflammation affect CD4 T cell subset requirements for specific AA remains uncertain. Here...
7.
Madden M, Ye X, Chi C, Fisher E, Wolf M, Needle G, et al.
J Immunol
. 2023 Jun;
211(4):563-575.
PMID: 37341499
Activated T cells undergo metabolic reprogramming to meet anabolic, differentiation, and functional demands. Glutamine supports many processes in activated T cells, and inhibition of glutamine metabolism alters T cell function...
8.
Patterson A, Needle G, Sugiura A, Chi C, Steiner K, Fisher E, et al.
bioRxiv
. 2023 Feb;
PMID: 36747715
Highlights: Inborn errors of immunity and metabolism have greater overlap than previously known deficiency causes an IEM but also selectively regulates T cell subset fate Loss of causes a T...