Daniele Passarella
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Explore the profile of Daniele Passarella including associated specialties, affiliations and a list of published articles.
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109
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806
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Recent Articles
1.
Pedrini M, Pozzi L, Sacchi F, Citarella A, Fasano V, Seneci P, et al.
Bioorg Med Chem
. 2025 Feb;
121:118124.
PMID: 39999646
SARS-CoV-2 is the virus responsible for the COVID-19 pandemic, which caused over 6.7 million deaths worldwide. The Spike protein plays a crucial role in the infection process, mediating the binding...
2.
Citarella A, Fiori A, Silvani A, Passarella D, Fasano V
ChemSusChem
. 2025 Jan;
:e202402538.
PMID: 39831740
The first successful synthesis of 1,2,3-triazoles using Cyrene as a biodegradable and non-toxic solvent in click chemistry has been developed. In contrast to previous methods, this sustainable approach allows product...
3.
Montoli A, Dimasi A, Guarnaccia M, Citarella A, Ronchi P, Blasi D, et al.
RSC Adv
. 2025 Jan;
15(2):870-874.
PMID: 39802475
Pyridines can be deuterated at the remote sites by treatment with KOBu in DMSO- , although without discrimination between the - and -position. Herein, base-catalyzed deuterations have been studied, computationally...
4.
Giustini A, Maiocchi A, Serangeli I, Pedrini M, Quintiliani A, Sabato V, et al.
Drug Dev Res
. 2025 Jan;
86(1):e70041.
PMID: 39749681
Familial encephalopathy with neuroserpin inclusion bodies (FENIB) is a neurodegenerative pathology caused by accumulation of mutant neuroserpin (NS) polymers inside the endoplasmic reticulum (ER) of neurons, leading to cellular toxicity...
5.
Citarella A, Petrella S, Moi D, Dimasi A, Braga T, Ruberto L, et al.
Bioorg Med Chem
. 2024 Nov;
115:117987.
PMID: 39509759
Cathepsins, key members of the papain-like family of cysteine proteases, are crucial for proteolysis processes within human cells, including osteolysis, immunomodulation and apoptosis. Recent research has highlighted the significant role...
6.
A novel, glutathione-activated prodrug of pimasertib loaded in liposomes for targeted cancer therapy
Amenta A, Comi S, Kravicz M, Sesana S, Antoniou A, Passarella D, et al.
RSC Med Chem
. 2024 Oct;
PMID: 39430954
Pimasertib, a potent antiproliferative drug, has been extensively studied for treating cancers characterized by dysregulation in the ERK/MAPK signaling pathway, such as melanoma. However, its therapeutic efficacy would greatly benefit...
7.
Citarella A, Cavinato M, Rosini E, Shehi H, Ballabio F, Camilloni C, et al.
ACS Med Chem Lett
. 2024 Sep;
15(9):1474-1481.
PMID: 39291031
A library of novel nicotinic acid derivatives, focusing on the modification of position 6 of the pyridine ring with (thio)ether functionalities, was mostly produced through an innovative green synthetic approach...
8.
Delgado A, Orlando P, Lanzi M, Benet-Buchholz J, Passarella D, Kleij A
Org Lett
. 2024 Aug;
26(36):7596-7600.
PMID: 39213514
Alkyne-functionalized oxetanes are presented as versatile substrates that in combination with amine reagents can be transformed into structurally diverse, chiral γ-amino alcohols featuring a tetrasubstituted tertiary stereocenter under Cu catalysis....
9.
Colombo E, Coppini D, Borsoi S, Fasano V, Bucci R, Bonato F, et al.
Chempluschem
. 2024 Jun;
89(10):e202400413.
PMID: 38924276
Epothilones are 16-membered macrolides that act as microtubule-targeting agents to tackle cancer. Many synthetic analogues have been investigated for their activity, yet often based on macrolide structures. A notable exception...
10.
Maiocchi A, Fumagalli M, Vismara M, Blanco A, Ciriello U, Paladino G, et al.
J Nat Prod
. 2024 Jun;
87(7):1725-1734.
PMID: 38889235
Despite millennia of therapeutic plant use, deliberate exploitation of 's diverse biomedical potential has only recently gained attention. Bioactivity studies focus mainly on cannabidiol (CBD) and tetrahydrocannabinol (THC) with limited...