Daniele Passarella
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Explore the profile of Daniele Passarella including associated specialties, affiliations and a list of published articles.
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109
Citations
806
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Recent Articles
11.
Pinzi L, Conze C, Bisi N, Torre G, Soliman A, Monteiro-Abreu N, et al.
Nat Commun
. 2024 Feb;
15(1):1679.
PMID: 38396035
Tauopathies such as Alzheimer's disease are characterized by aggregation and increased phosphorylation of the microtubule-associated protein tau. Tau's pathological changes are closely linked to neurodegeneration, making tau a prime candidate...
12.
Dimasi A, Failla M, Montoli A, Citarella A, Ronchi P, Passarella D, et al.
RSC Adv
. 2024 Feb;
14(8):5542-5546.
PMID: 38352680
Caerulomycins, natural alkaloids with antimicrobial properties, have been previously synthesized starting with highly pre-functionalized building blocks or requiring many functional group manipulations. In this work, we report the first total...
13.
Merve Aydin E, Canitez I, Colombo E, Princiotto S, Passarella D, Dallavalle S, et al.
Molecules
. 2023 Dec;
28(23).
PMID: 38067507
Ovarian cancer ranks as the eighth most prevalent form of cancer in women across the globe and stands as the third most frequent gynecological cancer, following cervical and endometrial cancers....
14.
Colombo E, Merve Aydin E, Canitez I, Polito L, Penconi M, Bossi A, et al.
ACS Med Chem Lett
. 2023 Oct;
14(10):1472-1477.
PMID: 37849561
The conjugation of tetraphenylethylene (TPE) with podophyllotoxin, -desacetylthiocolchicine, and cabazitaxel through a sebacic acid linker led to the formation of fluorescent nanoparticles. Dynamic light scattering (DLS) and photoluminescence spectroscopy were...
15.
Citarella A, Dimasi A, Moi D, Passarella D, Scala A, Piperno A, et al.
Biomolecules
. 2023 Sep;
13(9).
PMID: 37759739
The main protease (M) plays a pivotal role in the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is considered a highly conserved viral target. Disruption of the...
16.
Pedrini M, Iannielli A, Meneghelli L, Passarella D, Broccoli V, Seneci P
Pharmaceutics
. 2023 May;
15(5).
PMID: 37242709
The search for disease-modifying agents targeted against Parkinson's disease led us to rationally design a small array of six Anle138b-centered PROTACs, ,, , and ,, targeting αSynuclein (αSyn) aggregates for...
17.
Antoniou A, Nordio G, Di Paolo M, Colombo E, Gaffuri B, Polito L, et al.
Pharmaceuticals (Basel)
. 2023 May;
16(5).
PMID: 37242505
A potent nontoxic antitumor drug, 2-hydroxyoleic acid (, 2OHOA) used for membrane lipid therapy, was selected as a self-assembly inducer due to its ability to form nanoparticles (NPs) in water....
18.
Kumar K, Das R, Thapa B, Rakhecha B, Srivastava S, Savita K, et al.
Bioorg Med Chem
. 2023 May;
86:117300.
PMID: 37146520
Abnormal epigenetics has been recognised as an early event in tumour progression and aberrant acetylation of lysine in particular has been understood in tumorigenesis. Therefore, it has become an attractive...
19.
Citarella A, Moi D, Pedrini M, Perez-Pena H, Pieraccini S, Dimasi A, et al.
Org Biomol Chem
. 2023 Apr;
21(18):3811-3824.
PMID: 37078164
COVID-19 now ranks among the most devastating global pandemics in history. The causative virus, SARS-CoV-2, is a new human coronavirus (hCoV) that spreads among humans and animals. Great efforts have...
20.
Citarella A, Moi D, Pedrini M, Perez-Pena H, Pieraccini S, Stagno C, et al.
Molecules
. 2023 Jan;
28(2).
PMID: 36677572
SARS-CoV-2 M is a chymotrypsin-like cysteine protease playing a relevant role during the replication and infectivity of SARS-CoV-2, the coronavirus responsible for COVID-19. The binding site of M is characterized...