Daniel S Kantner
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Explore the profile of Daniel S Kantner including associated specialties, affiliations and a list of published articles.
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8
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64
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Recent Articles
1.
Liu J, Kuna R, Pinheiro L, Nguyen P, Welles J, Drummond J, et al.
Cell Metab
. 2024 Oct;
37(1):239-254.e7.
PMID: 39471816
ATP citrate lyase (ACLY) synthesizes acetyl-CoA for de novo lipogenesis (DNL), which is elevated in metabolic dysfunction-associated steatotic liver disease. Hepatic ACLY is inhibited by the LDL-cholesterol-lowering drug bempedoic acid...
2.
Kantner D, Megill E, Bostwick A, Yang V, Bekeova C, Van Scoyk A, et al.
Anal Biochem
. 2023 Nov;
685:115405.
PMID: 38016493
Acetyl-Coenzyme A is a central metabolite in catabolic and anabolic pathways as well as the acyl donor for acetylation reactions. Multiple quantitative measurement techniques for acetyl-CoA have been reported, including...
3.
Demetriadou C, Kantner D, Snyder N
J Clin Invest
. 2023 Nov;
133(22).
PMID: 37966112
Cardiac metabolism provides effects that extend beyond the transformation of energy for the heart to operate effectively. Some metabolites also function as signaling molecules and exert transcriptional changes. Heart failure...
4.
Lieberman W, Brown Z, Kantner D, Jing Y, Megill E, Evans N, et al.
J Am Chem Soc
. 2023 Jul;
145(30):16899-16905.
PMID: 37486078
Chemoproteomic profiling is a powerful approach to define the selectivity of small molecules and endogenous metabolites with the human proteome. In addition to mechanistic studies, proteome specificity profiling also has...
5.
Kantner D, Megill E, Bostwick A, Yang V, Bekeova C, Van Scoyk A, et al.
bioRxiv
. 2023 Jul;
PMID: 37398224
Acetyl-Coenzyme A is a central metabolite in catabolic and anabolic pathways as well as the acyl donor for acetylation reactions. Multiple quantitative measurement techniques for acetyl-CoA have been reported, including...
6.
Izzo L, Trefely S, Demetriadou C, Drummond J, Mizukami T, Kuprasertkul N, et al.
Sci Adv
. 2023 May;
9(18):eadf0115.
PMID: 37134161
The metabolite acetyl-CoA is necessary for both lipid synthesis in the cytosol and histone acetylation in the nucleus. The two canonical precursors to acetyl-CoA in the nuclear-cytoplasmic compartment are citrate...
7.
Flam E, Jang C, Murashige D, Yang Y, Morley M, Jung S, et al.
Nat Cardiovasc Res
. 2023 Feb;
1(9):817-829.
PMID: 36776621
Heart failure (HF) is a leading cause of mortality. Failing hearts undergo profound metabolic changes, but a comprehensive evaluation in humans is lacking. We integrate plasma and cardiac tissue metabolomics...
8.
Ma A, Kantner D, Beld J
Vitam Horm
. 2022 Mar;
119:43-63.
PMID: 35337629
Cobamides are a family of structurally-diverse cofactors which includes vitamin B and over a dozen natural analogs. Within the nucleotide loop structure, cobamide analogs have variable lower ligands that fall...