Christina Demetriadou
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Explore the profile of Christina Demetriadou including associated specialties, affiliations and a list of published articles.
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9
Citations
103
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Recent Articles
1.
Liu J, Kuna R, Pinheiro L, Nguyen P, Welles J, Drummond J, et al.
Cell Metab
. 2024 Oct;
37(1):239-254.e7.
PMID: 39471816
ATP citrate lyase (ACLY) synthesizes acetyl-CoA for de novo lipogenesis (DNL), which is elevated in metabolic dysfunction-associated steatotic liver disease. Hepatic ACLY is inhibited by the LDL-cholesterol-lowering drug bempedoic acid...
2.
Demetriadou C, Gibb A, Elrod J, Snyder N
Nat Cardiovasc Res
. 2024 Aug;
2(12):1109-1111.
PMID: 39188987
The molecular mechanisms that link propionyl-CoA metabolism and epigenetic regulation of gene expression are unclear, as are the implications for heart function. Now, new insights into the modulation of chromatin...
3.
Demetriadou C, Kantner D, Snyder N
J Clin Invest
. 2023 Nov;
133(22).
PMID: 37966112
Cardiac metabolism provides effects that extend beyond the transformation of energy for the heart to operate effectively. Some metabolites also function as signaling molecules and exert transcriptional changes. Heart failure...
4.
Lundgren P, Sharma P, Dohnalova L, Coleman K, Uhr G, Kircher S, et al.
Nat Metab
. 2023 Oct;
5(10):1691-1705.
PMID: 37783943
Sustained responses to transient environmental stimuli are important for survival. The mechanisms underlying long-term adaptations to temporary shifts in abiotic factors remain incompletely understood. Here, we find that transient cold...
5.
Izzo L, Trefely S, Demetriadou C, Drummond J, Mizukami T, Kuprasertkul N, et al.
Sci Adv
. 2023 May;
9(18):eadf0115.
PMID: 37134161
The metabolite acetyl-CoA is necessary for both lipid synthesis in the cytosol and histone acetylation in the nucleus. The two canonical precursors to acetyl-CoA in the nuclear-cytoplasmic compartment are citrate...
6.
Demetriadou C, Raoukka A, Charidemou E, Mylonas C, Michael C, Parekh S, et al.
Oncogene
. 2021 Nov;
41(4):571-585.
PMID: 34785778
Aberrant function of epigenetic modifiers plays an important role not only in the progression of cancer but also the development of drug resistance. N-alpha-acetyltransferase 40 (NAA40) is a highly specific...
7.
Demetriadou C, Koufaris C, Kirmizis A
Epigenetics Chromatin
. 2020 Jul;
13(1):29.
PMID: 32680559
Histone proteins are decorated with numerous post-(PTMs) or co-(CTMs) translational modifications mainly on their unstructured tails, but also on their globular domain. For many decades research on histone modifications has...
8.
Demetriadou C, Pavlou D, Mpekris F, Achilleos C, Stylianopoulos T, Zaravinos A, et al.
Cell Death Dis
. 2019 Mar;
10(3):236.
PMID: 30858358
N-alpha-acetyltransferase 40 (NAA40) catalyzes the transfer of an acetyl moiety to the alpha-amino group of serine 1 (S1) on histones H4 and H2A. Our previous studies linked NAA40 and its...
9.
Demetriadou C, Kirmizis A
Crit Rev Oncog
. 2018 Apr;
22(3-4):195-218.
PMID: 29604899
Histone acetyltransferases (HATs) catalyzing N-epsilon-lysine or N-alpha-terminal acetylation on histone and non-histone substrates are important epigenetic regulators controlling gene expression and chromatin structure. Deregulation of these enzymes by genetic or...