Nivitha Murali
Overview
Explore the profile of Nivitha Murali including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
39
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0
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Recent Articles
1.
Liu J, Kuna R, Pinheiro L, Nguyen P, Welles J, Drummond J, et al.
Cell Metab
. 2024 Oct;
37(1):239-254.e7.
PMID: 39471816
ATP citrate lyase (ACLY) synthesizes acetyl-CoA for de novo lipogenesis (DNL), which is elevated in metabolic dysfunction-associated steatotic liver disease. Hepatic ACLY is inhibited by the LDL-cholesterol-lowering drug bempedoic acid...
2.
Acosta J, Li Q, Freeburg N, Murali N, Indeglia A, Grothusen G, et al.
Nat Commun
. 2023 Jul;
14(1):4403.
PMID: 37479684
The p53 tumor suppressor regulates multiple context-dependent tumor suppressive programs. Although p53 is mutated in ~90% of small cell lung cancer (SCLC) tumors, how p53 mediates tumor suppression in this...
3.
Stieg D, Parris J, Yang T, Mirji G, Reiser S, Murali N, et al.
Cancer Res Commun
. 2023 Jul;
3(7):1200-1211.
PMID: 37441266
Significance: Findings presented here show that the P47S variant of influences the immune microenvironment, and the immune response to cancer. This is the first time that a naturally occurring genetic...
4.
Izzo L, Trefely S, Demetriadou C, Drummond J, Mizukami T, Kuprasertkul N, et al.
Sci Adv
. 2023 May;
9(18):eadf0115.
PMID: 37134161
The metabolite acetyl-CoA is necessary for both lipid synthesis in the cytosol and histone acetylation in the nucleus. The two canonical precursors to acetyl-CoA in the nuclear-cytoplasmic compartment are citrate...
5.
Gnanapradeepan K, Indeglia A, Stieg D, Clarke N, Shao C, Dougherty J, et al.
J Biol Chem
. 2022 Oct;
298(12):102637.
PMID: 36309086
The tumor suppressor protein p53 suppresses cancer by regulating processes such as apoptosis, cell cycle arrest, senescence, and ferroptosis, which is an iron-mediated and lipid peroxide-induced cell death pathway. Whereas...