Carmen Bekeova
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Explore the profile of Carmen Bekeova including associated specialties, affiliations and a list of published articles.
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12
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97
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Recent Articles
1.
Hasan P, Berezhnaya E, Rodriguez-Prados M, Weaver D, Bekeova C, Cartes-Saavedra B, et al.
Proc Natl Acad Sci U S A
. 2024 Aug;
121(35):e2402491121.
PMID: 39163336
Activating Ca-sensitive enzymes of oxidative metabolism while preventing calcium overload that leads to mitochondrial and cellular injury requires dynamic control of mitochondrial Ca uptake. This is ensured by the mitochondrial...
2.
Kantner D, Megill E, Bostwick A, Yang V, Bekeova C, Van Scoyk A, et al.
Anal Biochem
. 2023 Nov;
685:115405.
PMID: 38016493
Acetyl-Coenzyme A is a central metabolite in catabolic and anabolic pathways as well as the acyl donor for acetylation reactions. Multiple quantitative measurement techniques for acetyl-CoA have been reported, including...
3.
Bekeova C, Han J, Xu H, Kerr E, Blackburne B, Lynch S, et al.
bioRxiv
. 2023 Jul;
PMID: 37425757
Acyl-Coenzyme A (acyl-CoA) thioesters are compartmentalized intermediates that participate in in multiple metabolic reactions within the mitochondrial matrix. The limited availability of free CoA (CoASH) in the matrix raises the...
4.
Kantner D, Megill E, Bostwick A, Yang V, Bekeova C, Van Scoyk A, et al.
bioRxiv
. 2023 Jul;
PMID: 37398224
Acetyl-Coenzyme A is a central metabolite in catabolic and anabolic pathways as well as the acyl donor for acetylation reactions. Multiple quantitative measurement techniques for acetyl-CoA have been reported, including...
5.
Vasquez-Trincado C, Patel M, Sivaramakrishnan A, Bekeova C, Anderson-Pullinger L, Wang N, et al.
Hum Mol Genet
. 2021 Sep;
PMID: 34550363
Friedreich's ataxia (FRDA) is an inherited disorder caused by depletion of frataxin (FXN), a mitochondrial protein required for iron-sulfur cluster (ISC) biogenesis. Cardiac dysfunction is the main cause of death....
6.
Varner E, Trefely S, Bartee D, von Krusenstiern E, Izzo L, Bekeova C, et al.
Open Biol
. 2020 Sep;
10(9):200187.
PMID: 32961073
Lysine lactoylation is a recently described protein post-translational modification (PTM). However, the biochemical pathways responsible for this acylation remain unclear. Two metabolite-dependent mechanisms have been proposed: enzymatic histone lysine lactoylation...
7.
Bekeova C, Anderson-Pullinger L, Boye K, Boos F, Sharpadskaya Y, Herrmann J, et al.
J Biol Chem
. 2019 Nov;
294(50):19034-19047.
PMID: 31676684
Acyl-CoA thioesterases (Acots) hydrolyze fatty acyl-CoA esters. Acots in the mitochondrial matrix are poised to mitigate β-oxidation overload and maintain CoA availability. Several Acots associate with mitochondria, but whether they...
8.
Busche T, Novakova R, AlDilaimi A, Homerova D, Feckova L, Rezuchova B, et al.
Genome Announc
. 2018 Mar;
6(9).
PMID: 29496832
subsp. CCM 3239 produces the angucycline antibiotic auricin and was thought to be the type strain of We report the complete genome sequence of this strain, which consists of a...
9.
Mingyar E, Novakova R, Knirschova R, Feckova L, Bekeova C, Kormanec J
Gene
. 2017 Nov;
642:313-323.
PMID: 29155332
We previously identified the aur1 gene cluster, responsible for the production of the angucycline antibiotic auricin in Streptomyces aureofaciens CCM 3239. Pulse-field gel electrophoresis showed a single, 241kb linear plasmid,...
10.
Bekeova C, Rehakova A, Feckova L, Vlckova S, Novakova R, Mingyar E, et al.
Appl Microbiol Biotechnol
. 2015 Dec;
100(7):3177-95.
PMID: 26685675
We previously identified the aur1 gene cluster which produces the angucycline antibiotic auricin. Preliminary characterisation of auricin revealed that it is modified by a single aminodeoxysugar, D-forosamine. Here we characterise...