Phuong T T Nguyen
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Explore the profile of Phuong T T Nguyen including associated specialties, affiliations and a list of published articles.
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15
Citations
794
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Recent Articles
1.
Nguyen P, Shiue M, Kuprasertkul N, Costa-Pinheiro P, Izzo L, Pinheiro L, et al.
Cell Rep
. 2025 Feb;
44(2):115284.
PMID: 39932848
ATP-citrate lyase (ACLY) generates cytosolic acetyl-coenzyme A (acetyl-CoA) for lipid synthesis and is a promising therapeutic target in diseases with altered lipid metabolism. Here, we developed inducible whole-body Acly-knockout mice...
2.
Liu J, Kuna R, Pinheiro L, Nguyen P, Welles J, Drummond J, et al.
Cell Metab
. 2024 Oct;
37(1):239-254.e7.
PMID: 39471816
ATP citrate lyase (ACLY) synthesizes acetyl-CoA for de novo lipogenesis (DNL), which is elevated in metabolic dysfunction-associated steatotic liver disease. Hepatic ACLY is inhibited by the LDL-cholesterol-lowering drug bempedoic acid...
3.
Supplee J, Affronti H, Duan R, Brooks R, Stine Z, Nguyen P, et al.
J Biol Chem
. 2024 May;
300(7):107418.
PMID: 38815867
ATP-citrate lyase (ACLY) links carbohydrate and lipid metabolism and provides nucleocytosolic acetyl-CoA for protein acetylation. ACLY has two major splice isoforms: the full-length canonical "long" isoform and an uncharacterized "short"...
4.
Izzo L, Trefely S, Demetriadou C, Drummond J, Mizukami T, Kuprasertkul N, et al.
Sci Adv
. 2023 May;
9(18):eadf0115.
PMID: 37134161
The metabolite acetyl-CoA is necessary for both lipid synthesis in the cytosol and histone acetylation in the nucleus. The two canonical precursors to acetyl-CoA in the nuclear-cytoplasmic compartment are citrate...
5.
Greenwood D, Ramsey H, Nguyen P, Patterson A, Voss K, Bader J, et al.
Immunohorizons
. 2022 Dec;
6(12):837-850.
PMID: 36547387
Hematopoiesis integrates cytokine signaling, metabolism, and epigenetic modifications to regulate blood cell generation. These processes are linked, as metabolites provide essential substrates for epigenetic marks. In this study, we demonstrate...
6.
Cheng Y, Medina A, Yao Z, Basu M, Natekar J, Lang J, et al.
Cell Rep
. 2022 Jun;
39(9):110885.
PMID: 35649379
Physiological blood-tissue barriers play a critical role in separating the circulation from immune-privileged sites and denying access to blood-borne viruses. The mechanism of virus restriction by these barriers is poorly...
7.
Huang W, Wong S, Pather S, Nguyen P, Zhang F, Zhang D, et al.
Cell Stem Cell
. 2021 May;
28(9):1657-1670.e10.
PMID: 33961804
Human brain organoids represent remarkable platforms for recapitulating features of human brain development and diseases. Existing organoid models do not resolve fine brain subregions, such as different nuclei in the...
8.
Everett R, Flores K, Henscheid N, Lagergren J, Larripa K, Li D, et al.
Math Biosci Eng
. 2020 Sep;
17(4):3660-3709.
PMID: 32987550
Intra-tumor and inter-patient heterogeneity are two challenges in developing mathematical models for precision medicine diagnostics. Here we review several techniques that can be used to aid the mathematical modeller in...
9.
Qian X, Su Y, Adam C, Deutschmann A, Pather S, Goldberg E, et al.
Cell Stem Cell
. 2020 Mar;
26(5):766-781.e9.
PMID: 32142682
Human brain organoids provide unique platforms for modeling development and diseases by recapitulating the architecture of the embryonic brain. However, current organoid methods are limited by interior hypoxia and cell...
10.
Jacob F, Salinas R, Zhang D, Nguyen P, Schnoll J, Wong S, et al.
Cell
. 2019 Dec;
180(1):188-204.e22.
PMID: 31883794
Glioblastomas exhibit vast inter- and intra-tumoral heterogeneity, complicating the development of effective therapeutic strategies. Current in vitro models are limited in preserving the cellular and mutational diversity of parental tumors...