Daniel J Sprague
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Explore the profile of Daniel J Sprague including associated specialties, affiliations and a list of published articles.
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19
Citations
77
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Recent Articles
1.
Sprague D, Rohr C, Marchant J
Front Parasitol
. 2025 Jan;
3():1349623.
PMID: 39817176
Infections caused by parasitic flatworms impart a significant disease burden. This is well exemplified by the neglected tropical disease schistosomiasis, which afflicts millions of people worldwide. The anti-schistosomal activity of...
2.
Nunez R, Sidlowski P, Steen E, Wynia-Smith S, Sprague D, Keyes R, et al.
ACS Chem Biol
. 2024 Nov;
19(12):2418-2428.
PMID: 39556662
Histone lysine lactylation (Kla) regulates inflammatory gene expression in activated macrophages and mediates the polarization of inflammatory (M1) to reparative (M2) macrophages. However, the molecular mechanisms and key protein players...
3.
Sprague D, Park S, Gramberg S, Bauer L, Rohr C, Chulkov E, et al.
Nat Struct Mol Biol
. 2024 May;
31(9):1386-1393.
PMID: 38714890
Diseases caused by parasitic flatworms impart a considerable healthcare burden worldwide. Many of these diseases-for example, the parasitic blood fluke infection schistosomiasis-are treated with the drug praziquantel (PZQ). However, PZQ...
4.
Jones Lipinski R, Stancill J, Nunez R, Wynia-Smith S, Sprague D, Nord J, et al.
Am J Physiol Regul Integr Comp Physiol
. 2024 Apr;
326(6):R515-R527.
PMID: 38618911
Inhibition of the bromodomain and extraterminal domain (BET) protein family is a potential strategy to prevent and treat diabetes; however, the clinical use of BET bromodomain inhibitors (BETis) is associated...
5.
Park S, Sprague D, Rohr C, Chulkov E, Petrow I, Kumar S, et al.
J Biol Chem
. 2023 Dec;
300(1):105528.
PMID: 38043794
Parasitic flatworms cause various clinical and veterinary infections that impart a huge burden worldwide. The most clinically impactful infection is schistosomiasis, a neglected tropical disease caused by parasitic blood flukes....
6.
Sprague D, Kaethner M, Park S, Rohr C, Harris J, Maillard D, et al.
ACS Med Chem Lett
. 2023 Nov;
14(11):1537-1543.
PMID: 37970586
The anthelmintic drug praziquantel remains a key clinical therapy for treating various diseases caused by parasitic flatworms. The parasite target of praziquantel has remained undefined despite longstanding usage in the...
7.
Sprague D, Park S, Gramberg S, Bauer L, Rohr C, Chulkov E, et al.
bioRxiv
. 2023 Oct;
PMID: 37790347
Diseases caused by parasitic flatworms impart a considerable healthcare burden worldwide. Many of these diseases - for example, the parasitic blood fluke infection, schistosomiasis - are treated with the drug...
8.
Malcolm N, Palkovic B, Sprague D, Calkins M, Lanham J, Halberstadt A, et al.
iScience
. 2023 Jul;
26(7):107121.
PMID: 37416459
Synthetic opioids are increasingly challenging to combat the opioid epidemic and act primarily at opioid receptors, chiefly the G protein-coupled receptor (GPCR) μ-opioid receptor (MOR), which signals through G protein-dependent...
9.
Yahya N, Lanham J, Sprague D, Palygin O, McCorvy J, Marchant J
Am J Physiol Cell Physiol
. 2023 Jan;
324(2):C573-C587.
PMID: 36622066
The anthelmintic drug praziquantel (PZQ) causes contraction of parasitic schistosomes as well as constriction of blood vessels within the mesenteric vasculature of the host where the adult blood flukes reside....
10.
Rohr C, Sprague D, Park S, Malcolm N, Marchant J
Proc Natl Acad Sci U S A
. 2022 Dec;
120(1):e2217732120.
PMID: 36574686
The drug praziquantel (PZQ) is the key clinical therapy for treating schistosomiasis and other infections caused by parasitic flatworms. A schistosome target for PZQ was recently identified- a transient receptor...